鬼针草中黄酮类化学成分的药代动力学研究进展

鬼针草是我国的传统中药材，现代药学研究发现有抗炎、抗氧化、抗纤维化等药理活性，临床用于肝炎、风湿等疾病。黄酮类是其主要活性部位，从鬼针草中提取的鬼针草总黄酮（TFB）具有良好的临床应用前景。近年来其中一些成分在体内的药代动力学研究资料不断丰富，为了进一步明确鬼针草中黄酮类成分在体内的吸收、分布、代谢、排泄过程，该文就近年来鬼针草中含有的黄酮类化学成分的药代动力学研究进展进行综述，为相关研究提供参考。

Research development of chemical composition and pharmacokinetics of flavonoids in Bidens bipinnata L.

Bidens bipinnata L.,which is well known in China as a traditional Chinese medicine,has been used to treat hepatitis in clin-ics for many years,and also can be used in the treatment of hepatitis,rheumatism et al.Some satisfactory pharmacological activities has been found in anti-inflammatory,antioxidation,anti-fibrosis and so on.As the main active part of Bidens bipinnata L.total,flavonoids of Bidens bipinnata L.(TFB)has a broad prospect in clinical application.As further studies continue,pharmacokinetics research about main flavonoids from Bidens bipinnata L.constantly increase.In order to research the processes of absorbtion,distribution,metabolism and excretion in vivo,in this review,we make a summary on current understanding of pharmacokinetics of TFB by searching for relevant literatures,pharmacokinetics of main flavonoids were summarized in this article.