| 长春西汀纳米结构脂质载体的体外释放研究 |
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| 引用本文： | 赵昱,杨春荣,王宏媛,缪淑霞,王莹,周泯江.长春西汀纳米结构脂质载体的体外释放研究[J].黑龙江医药科学,2012,35(3):25-26. |
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| 作者姓名： | 赵昱 杨春荣 王宏媛 缪淑霞 王莹 周泯江 |
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| 作者单位： | 1. 佳木斯大学药学院,黑龙江省生物药制剂重点实验室,黑龙江佳木斯154007
2. 佳木斯大学附属第一医院药剂科,黑龙江佳木斯,154003 |
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| 基金项目： | 黑龙江省自然科学基金，黑龙江省卫生厅资助项目 |
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| 摘 要： | 目的：制备长春西汀纳米结构脂质载体,考察其体外释放规律。方法：选择pH7.4的磷酸盐缓冲液（PBS）作为释放介质,采用透析法测定长春西汀纳米结构脂质载体的体外释放。结果：长春西汀纳米结构脂质载体在24h释放为44%,药物在体外呈现缓释释放,符合Weibull分布。结论：所制备长春西汀纳米结构脂质载体体外缓释效果良好。
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| 关 键 词： | 长春西汀 纳米结构脂质载体 熔融超声法 体外释放 |
Research in vitro release of vinpocetine loaded nanostructured lipid carriers |
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| ZHAO Yu
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YANG Chun-rong
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WANG Hong-yuan
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MIAO Shu-xia
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WANG Ying
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ZHOU Min-jiang.Research in vitro release of vinpocetine loaded nanostructured lipid carriers[J].Heilongjiang Medicine and Pharmacy,2012,35(3):25-26. |
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| Authors: | ZHAO Yu YANG Chun-rong WANG Hong-yuan MIAO Shu-xia WANG Ying ZHOU Min-jiang |
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| Affiliation: | 1(1.The Key Laboratory of Biological Medicine Preparations of Heilongjiang Province,College Pharmacy of Jiamusi University,Jiamusi 154007,China;2.Department of Pharmacy,the First Affiliated Hospital of Jiamusi University,Jiamusi 154003,China) |
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| Abstract: | Objective:To prepare vinpocetine loaded nanostructured lipid carriers(NLC) and to evaluate its releasing features in vitro.Method:In vitro release rate of vinpocetine loaded nanostructured lipid carriers by the dialysis method with pH 7.4 PBS as medium.Result:In vitro release of vinpocetine loaded nanostructured lipid carriers was sustained-release and subject to Weibull model,accumulative rate of 44% in 24h.Conclusions:The vinpocetine loaded nanostructured lipid carriers were prepared by melt ultrasonication method,having good sustained-release effect. |
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| Keywords: | vinpocetine nanostructured lipid carriers melt ultrasonication method in vitro release |
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