血管回声跟踪技术评价颈动脉硬化与肠道菌群 失调的相关性研究

目的 应用血管回声跟踪技术（ET）评价颈动脉硬化与肠道菌群失调相关性。方法 选取2017 年 7 月—2018 年4 月唐山市人民医院接诊的117 例颈动脉粥样硬化患者作为观察组，另取同期健康体检人群117 例作为对照组。两组行血管ET 评价和肠道菌群检测。结果 观察组僵硬度、压力应变弹性系数、放射波增 压指数、脉搏波传导速度、内膜中层厚度、消化链球菌、葡萄球菌、肠球菌及大肠埃希菌高于对照组（P <0.05）； 观察组顺应性、双歧杆菌、乳酸杆菌及酵母菌低于对照组（P <0.05）。颈动脉粥样硬化指标（僵硬度、压力 应变弹性系数、放射波增压指数、脉搏波传导速度及内膜中层厚度）与肠道菌群（双歧杆菌、乳酸杆菌、酵 母菌）呈负相关（P <0.05），与肠道菌群（消化链球菌、葡萄球菌、肠球菌、大肠埃希菌）呈正相关（P <0.05）。 颈动脉粥样硬化指标（顺应性）与肠道菌群（双歧杆菌、乳酸杆菌、酵母菌）呈正相关，与肠道菌群（消化 链球菌、葡萄球菌、肠球菌、大肠埃希菌）呈负相关（P <0.05）。结论 血管ET 技术评价颈动脉粥样硬化 的临床价值较高，且与肠道菌群的关系密切，值得临床推广应用。

Relevance between intestinal flora disorder and carotid atherosclerosis by ET

Objective To investigate relevance between intestinal flora disorder and carotid atherosclerosis by ET. Methods Totally 117 patients with carotid atherosclerosis were selected in hospital from July 2017 to April 2018 as observation group. 117 health checkup people were selected at same period as control group. All people treated echo tracking technique evaluation and intestinal flora detection. Results Stiffness, pressure strain elasticity coefficient, radio wave pressure index, pulse wave conduction velocity, middle intima thickness, streptococcus, staphylococci, enterococci, escherichia coli in observation group were higher than those in control group (P < 0.05). Compliance, bifidobacteria, lactobacillus and yeast in observation group were lower than those in control group (P < 0.05). Carotid atherosclerosis indicators (stiffness, pressure-strain elasticity coefficient, radiation wave pressure index, pulse wave velocity and intima-media thickness) were negatively correlated with intestinal flora (bifidobacterium, lactobacillus, yeast) (P < 0.05), and intestinal flora (digestive streptococcus, staphylococcus, enterococcus, Escherichia coli). There was a positive correlation (P < 0.05). The index of carotid atherosclerosis (compliance) was positively correlated with intestinal flora (bifidobacterium, lactobacillus, yeast) and negatively correlated with intestinal flora (digestive streptococcus, staphylococcus, enterococcus, Escherichia coli) (P < 0.05). Conclusions The clinical value of vascular ET in evaluating carotid atherosclerosis is high, and it is closely related to intestinal flora, which is worthy of clinical application.