宫颈病变检测人乳头瘤病毒感染的意义

目的 探讨人乳头瘤病毒（HPV）感染与宫颈病变的关系.方法 用荧光定量PCR法检测15例正常宫颈,57例宫颈尖锐湿疣,78例宫颈上皮内瘤变（CIN）,43例宫颈尖锐湿疣合并CIN,13例宫颈癌的HPV感染情况.结果 本组宫颈病变中HPV感染率92.72％,单一型HPV感染率89.52％,高危型HPV感染率98.25％;宫颈尖锐湿疣以HPV52感染为主（41.18％）;CIN以HPV16感染为主（41.67％）;尖锐湿疣合并CIN感染HPV58者占25.00％,感染HPV16和HPV52的各占15.00％; 60.00％宫颈癌感染HPV16;多重型HPV感染以HPV亚型双重感染为主.结论 HPV检测对于宫颈病变的筛查及临床分流监测有重要价值.

Significance of infection with human papillomavirus in cervix lesions

Objective To investigate the relationship between human papillomavirus infection and cervix lesions. Methods HPV infection was detected by fluorogenic quantitative polymerase chain reaction in all specimens included 15 cases of normal cervix, 57 cases of cdrvical condyloma acuminatum, 78 cases of cervical intraepithelial neoplasia （CIN）, 43 cases of cervical condyloma acuminatum combining CIN, 13 cases of cervical carcinoma. Results In this groups of cervix lesions, HPV infection rate was 92.72%, HPV single infection rate was 89.52%, high!risk HPV sub- types infection rate was 98.25%%. Cervical condyloma acurninatum cases were most commonly infected with HPV52 （41.18%）. CIN cases were most commonly infected with HPV16 （41.67%）. Cervical condyloma acuminatum combining CIN cases were more often infected with HPV58 （25.00%）, HPV16 （15.00%） and HPV52 （15.00%）. 60.00% of cervical carcinoma cases were infected with HPV16. Multiple infection HPV subtype cases were more often infected with dual infection subtype. Conclusion The detection of HPV infection has great value for screening and triage of patients with cervix lesions.