| 2,6-二氯嘌呤核苷的合成工艺研究 |
| |
| 引用本文： | 申艳红,刘启宾,李淑君,渠桂荣.2,6-二氯嘌呤核苷的合成工艺研究[J].精细化工中间体,2007,37(3):35-37. |
| |
| 作者姓名： | 申艳红 刘启宾 李淑君 渠桂荣 |
| |
| 作者单位： | 1. 安阳工学院,河南,安阳,455000;河南师范大学,河南,新乡,453002
2. 河南师范大学,河南,新乡,453002 |
| |
| 基金项目： | 国家自然科学基金资助项目(20372018)。 |
| |
| 摘 要： | 以2,6-二氯嘌呤和1,2,3,5-四乙酰核糖为原料,四氯化锡为催化剂,130℃下反应18min,得到中间体2,6-二氯嘌呤-2',3',5'-三乙酰基核苷。该中间体在硫酸-甲醇中脱酰基得到2,6-二氯嘌呤核苷,为白色粉状结晶,收率63%,纯度(HPLC)≥99.0%,熔点152￣154℃。
|
| 关 键 词： | 2 6-二氯嘌呤核苷 2 6-二氯嘌呤 1 2 3 5-四乙酰基核糖 |
| 文章编号： | 1009-9212（2007）03-0035-03 |
| 修稿时间： | 2007-04-02 |
Synthesis of 2,6-Dichloroadenosine |
| |
| SHEN Yan-hong,LIU Qi-bin,LI Shu-jun,QU Gui-rong.Synthesis of 2,6-Dichloroadenosine[J].Fine Chemical Intermediates,2007,37(3):35-37. |
| |
| Authors: | SHEN Yan-hong LIU Qi-bin LI Shu-jun QU Gui-rong |
| |
| Affiliation: | 1. Department of Chemical Engineering, Anyang University, Anyang 455000, China; 2. College of Chemistry and Environmental Sciences, Henan Normal University, Xinxiang 453002, China |
| |
| Abstract: | A new method for synthesizing 2,6-dichloroadenosine was reported in the paper. The starting material 2,6-dichloropurine was condensed with 1,2,3,5-tetraacetylribofuranose at 130℃ for 18 minutes to form 2',3',5'-triacetyl-2,6-dichloroadenosine,which was deprotected in H2SO4-CH3OH at 0~5℃ to give the target product 2,6-dichloroadenosine as a white crystalline powder. The yield was 63%,purity(HPLC)≥99.0%,and the melting point of the product was 152~154℃. |
| |
| Keywords: | 2 6-dichloroadenosine 2 6-dichloropurine 1 2 3 5-tetraacetylribofuranose |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
