Continuous glucose monitoring in the patients with diabetic nephropathy |
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Authors: | Feng Wang Dong-sheng Cheng Nian-song Wang Wen-hui Li Yu-qian Bao Jian Zhou Wei-ping Jia |
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Affiliation: | (1) Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Jongno-gu, Seoul, 110-744, Republic of Korea;(2) Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea; |
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Abstract: | The aim of this study was to compare the difference of blood glucose (BG) fluctuation in the patients of type-2 diabetes mellitus
(DM-2) with and without clinical diagnosed diabetic nephropathy (DN) by the continuous glucose monitoring system (CGMS). Thirty
DM-2 patients with clinical diagnosed DN and fifteen DM-2 patients without complication underwent continuous glucose monitoring
for 3 days (72 h) by CGMS. The difference of daily glucose fluctuation in both groups was compared by the parameter of CGMS.
The 24-h mean blood glucose (MBG), minimal BG (MIN-BG), area under curve of BG over 7.8 (AUC7.8), percentage of time of BG
over 7.8 (PT7.8), area under curve of BG over 11.1 (AUC11.1), percentage of time of BG over 11.1 (PT11.1), as well as mean
of daily difference (MODD) were significantly increased in the group of DN, compared with those in the group of DM-2 without
complication (all statistic probability P <0.05). No statistical significance of mean amplitude of glycaemic excursion (MAGE) was found. In the group of DN, MBG, standard
deviation of blood glucose (SDBG), large amplitude of glycaemic excursion (LAGE), AUC7.8, PT7.8, AUC11.1, PT11.1, MAGE and
MODD were (10.7±1.9)mmol/L, (2.5±1.3)mmol/L, (9.2±3.9)mmol/L, 3.2±1.7, (81±18)%, 1.2±1.0, (42±24)%, (5.8±2.5)mmol/L and (2.6±1.5)mmol/L,
respectively. The study showed that the BG level of the patients with DN fluctuated throughout the day. MBG of the patients
with DN was higher than that of the patients of DM-2 without complications, with the characteristics of long-lasting high
BG period, dramatic instability during the day and especially high postprandial blood glucose. CGMS is a useful tool for physicians
to know the details of the change of BG in the patients with DN. |
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