| 长穗桑茎皮中的酚类成分及其抗炎和细胞毒活性 |
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| 引用本文： | 谭永霞,刘超,陈若芸.长穗桑茎皮中的酚类成分及其抗炎和细胞毒活性[J].中国中药杂志,2010,35(20):2700-2703. |
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| 作者姓名： | 谭永霞 刘超 陈若芸 |
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| 作者单位： | 中国医学科学院北京协和医学院药物研究所中草药物质基础与资源利用教育部重点实验室,北京,100050 |
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| 基金项目： | 国家科技重大专项综合平台项目(2009ZX09301-003-12-1) |
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| 摘 要： | 目的:研究长穗桑茎皮中具有抗炎和细胞毒活性的化学成分。方法:采用各种柱色谱对长穗桑茎皮95%乙醇提取物的醋酸乙酯部位进行分离纯化,通过NMR,MS等波谱分析手段鉴定化合物结构。结果:从醋酸乙酯部位中分离得到9个酚类化合物,其中6个黄酮类化合物,3个二苯乙烯类化合物。分别鉴定为槲皮素(1),5,7,3,′4′-四羟基-3-甲氧基黄酮(2),norartocarpanone(3),二氢山柰酚(4),euchrenone a7(5),morachalcone A(6),白藜芦醇(7),高白藜芦醇(8),4′-异戊烯基高白藜芦醇(9)。化合物1~8分别进行了抗炎和细胞毒活性筛选。结论:化合物1~9均为首次从该植物中分离得到。其中化合物6和8浓度在1.0×10-5mol.L-1时对血小板活化因子刺激的多形核白细胞β-葡萄糖苷酸酶释放的抑制率分别为76.8%,94.2%;化合物2和8分别对人卵巢癌细胞(A2780)和人胃癌细胞(BGC-823)有选择性细胞毒活性,IC50分别为0.66,1.31μmol.L-1。
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| 关 键 词： | 长穗桑 黄酮类 二苯乙烯类 抗炎 细胞毒 |
| 收稿时间： | 1/6/2010 12:00:00 AM |
Phenolic constituents from stem bark of Morus wittiorum and their anti-inflammation and cytotoxicity |
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| TAN Yongxi,LIU Chao and CHEN Ruoyun.Phenolic constituents from stem bark of Morus wittiorum and their anti-inflammation and cytotoxicity[J].China Journal of Chinese Materia Medica,2010,35(20):2700-2703. |
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| Authors: | TAN Yongxi LIU Chao and CHEN Ruoyun |
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| Affiliation: | Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine of Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China;Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine of Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China;Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine of Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China |
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| Abstract: | |
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| Keywords: | Morus wittiorum flavonoids stilbenoids anti-inflammation cytotoxicity |
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