CD184表达与急性髓细胞白血病预后相关因素分析

目的:探讨急性髓细胞白血病(AML)患者CD184表达与预后关系。方法:应用流式细胞术(FCM)检测了54例初治急性髓细胞白血病患者CD184表达情况,并分析CD184表达与CR1率,髓外浸润,复发率相关性。结果:CD184阳性组AML患者CR1率低,髓外浸润,复发率均较CD184阴性组增高,有统计学差异(P<0.05);CR1组患者CD184水平较非CR1组患者低,有统计学差异(P<0.05)。结论:CD184高表达与CR1率低,髓外浸润,复发等不良预后有关;CD184是急性髓细胞白血病预后预测因子。

The Relationship between CD184 Expression and Related Prognosis Factors in Acute Myeloid Leukemia

Objective:Investigate the relationship between CD184 expression and prognosis in acute myeloid leukemia(AML) patient.Methods:The CD184 expressions were detected by flow cytometry(FCM) in 54 newly diagnosed acute myeloid leukemia(AML) patients,and the relationship between CD184 expression and CR1,extramedullary infiltration,recurernce rate also were analyzed.Results:The extramedullary infiltration and recurernce rate in CD184 positive group were all higher than CD184 negative group,and the CR1 rate was lower.and have significantly statistic difference(P<0.05).The CD184 expression levels in CR1 group were lower than non-CR1 group,and has statistic difference(P<0.05).Conclusion:The high level of CD184 expression has closely associated with poor prognosis factor such as low level of CR1,extramedullary infiltration and relapse;CD184 expression is an prognostic factor in AML.