氟比洛芬酯超前镇痛对骨科手术患者的影响

目的观察氟比洛芬酯超前镇痛对骨科手术患者血流动力学和炎性细胞因子的影响。方法选取2009年3月-2010年12月骨科病房收治的100例ASAⅠ～Ⅱ级择期骨科手术需全麻的患者,按照随机原则分为对照组和实验组,每组50例。监测插管后注入脂肪乳的对照组和插管后注射氟比洛芬酯注射液的实验组的HR、MAP、拔管后的口述疼痛评分、VAS评分、术前和术后的Hs-CRP、IL-6、TNF-α。结果实验组患者T1、T2、T3时点的HR和MAP、口述疼痛评分、各时段VAS评分、术后Hs-CRP、IL-6和TNF-α均显著低于对照组(P<0.05)。结论氟比洛芬酯超前镇痛不但可有效预防骨科手术患者术后急性疼痛,而且能降低机体炎性反应,增加血流动力学的稳定性。

Efficacy of Flurbiprofen Axetil for Preemptive Analgesia in Patients Undergoing Orthopedic Surgery

Objective To investigate the effects of flurbiprofen axetil for preemptive analgesia on the hemodynamics and inflammatory mediators in patients undergoing orthopaedic.Methods One hundred patients with ASAⅠ-Ⅱ diseases needed general anesthesia for selective orthopaedic operation from March 2009 to December 2010 were selected and divided into control group and experimental group randomly(50 cases in each group).After the incubation,the control group received the fat emulsion injection,while the experimental group received the Flurbiprofen injection.HR,MAP,VRS,VAS,levels of Hs-CRP,IL-6 and TNF-α before and after operation were measured in both groups.Results HR and MAP in T1,T2,T3 stage,VRS,VAS,the levels of Hs-CRP,IL-6 and TNF-α after surgery in experimental group were lower than those in control group(P<0.05).Conclusion Flurbiprofen axetil for preemptive analgesia can not only prevent the acute postoperative pain,but also reduce the systemic inflammatory response,and improve hemodynamics in orthopaedic surgery.