丙泊酚复合小剂量舒芬太尼用于无痛人流的疗效分析

目的探讨丙泊酚复合舒芬太尼用于无痛人流麻醉的效果和安全性。方法选择门诊ASAⅠ~Ⅱ级自愿接受无痛人工流产的手术患者150例,随机分为对照组与观察组（每组75例）。在静脉丙泊酚给药前,对照组予芬太尼1μg/kg,而观察组予舒芬太尼0.1μg/kg;观察并记录两组的麻醉前、术中的HR、Bp、RR和SpO2变化,记录诱导时间、苏醒时间、丙泊酚用量、术后宫缩痛及其它不良反应等。结果丙泊酚用量治疗组少于对照组（P〈0.05）,呼吸抑制发生率对照组80%,治疗组50%,术后宫缩痛治疗组明显少于对照组（P〈0.05）;两组术中血压、心率、脉搏氧饱和度比较差异无显著性。结论舒芬太尼复合丙泊酚静脉麻醉行无痛人工流产术可以减少丙泊酚用量和呼吸抑制的发生,镇痛效果显著,而不良反应未见增加。

The clinical observation of propofol combined with sufentanil on anesthesia for artificial abortion

Objective To compare the efficacy and safety of propofol combined with low dose sufentanil or ketamine on anesthesia for induced abortion. Methods 150 ASAⅠ~Ⅱpatients of early pregnancy with voluntarily induced abortion were randomized into control group and observation group（75 cases each group）.Ketamine 0.5mg/kg combined with propofol in control group while sufentanil 0.1ug/kg combined with propofol was administered in observation group.The change of heat rate,blood pressure,breath rate and oxygen saturation were recorded during operation.Other outcome including intraoperative and postoperative analgesia effect,the total dose of propofol,operation duration,the time for emergence and leaving hospital,and adverse events,were observed.Results The intraoperative and postoperative analgesia effects in observation group were better than that in control group（P0.05）.In addition,both the time for emergence and leaving hospital in observation group were shorter than that in control group（P0.05）.Conclusions Propofol combined with sufentanil on induced abortion is satisfactied with the anesthetic effect,reducing the dose of propofol,intraoperative cyclostationarity,the rapid recovery after anesthesia,can be safely used for gynecological clinic abortion.