| 豆腐果苷理化常数的测定 |
| |
| 引用本文： | 贺建昌,郎丽巍,张青,董丽春,陈芳,徐贵丽.豆腐果苷理化常数的测定[J].中国药房,2010(1):23-25. |
| |
| 作者姓名： | 贺建昌 郎丽巍 张青 董丽春 陈芳 徐贵丽 |
| |
| 作者单位： | 成都军区昆明总医院药学部; |
| |
| 基金项目： | 云南省自然科学基金资助项目(2003C0016R) |
| |
| 摘 要： | 目的:测定豆腐果苷油水分配系数、溶解度和pKa值等理化常数。方法:参照《中国药典》(2005版)相关方法测定豆腐果苷在不同水溶液及不同有机溶剂中的近似溶解度;采用电位滴定法测定豆腐果苷的pKa值;采用摇瓶法测定豆腐果苷在不同的pH下的表观油水分配系数。结果:豆腐果苷属微溶药物,且在乙醚、乙酸乙酯和氯仿等有机溶剂中几乎不溶;豆腐果苷显弱酸性,pKa值为5.65±0.13。豆腐果苷的表观油水分配系数随pH值的升高而降低,且符合logP=-0.0211pH-1.0174的函数关系。在生理条件pH7.4时,豆腐果苷表观油水分配系数为0.067。在(25±0.1)℃条件下,豆腐果苷真实油水分配系数为0.0834。结论:豆腐果苷是一种脂溶性较差的弱酸性微溶药物。
|
| 关 键 词： | 豆腐果苷 近似溶解度 解离常数 表观油水分配系数 |
Study on Physicochemical Properties of Helicid |
| |
| HE Jian-chang,LANG Li-wei,ZHANG Qing,DONG Li-chun,CHEN Fang,XU Gui-li.Study on Physicochemical Properties of Helicid[J].China Pharmacy,2010(1):23-25. |
| |
| Authors: | HE Jian-chang LANG Li-wei ZHANG Qing DONG Li-chun CHEN Fang XU Gui-li |
| |
| Affiliation: | HE Jian-chang,LANG Li-wei,ZHANG Qing,DONG Li-chun,CHEN Fang,XU Gui-li(Dept.of Pharmacy,Kunming General Hospital of Chengdu Military Comm,,Kunming 650032,China) |
| |
| Abstract: | OBJECTIVE:To determine the physicochemical properties of helicid,such as oil/water partition coefficient,solubility and pKa value.METHODS:The approximate solubility of helicid in different aqueous solutions and organic solvents were determined according to the method specified in Chinese Pharmacopeia(2005 edition).The dissociation constant(pKa) and apparent oil/water partition coefficient of helicid in different pH condition were determined by using the potential titration method and shake-flask method,resp... |
| |
| Keywords: | Helicid Approximate solubility Dissociation constant Apparent oil/water partition coefficient |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
