新型冠状病毒肺炎患者恢复期肛拭子中SARS-CoV-2核酸检测结果评价

目的 分析新型冠状病毒肺炎（COVID-19）患者在恢复期肛拭子标本中新型冠状病毒（SARS-CoV-2）核 酸的检出率及其临床价值。方法 对我院确诊的COVID-19患者痰液、咽拭子和肛拭子3种来源的标本同期进行 SARS-CoV-2核酸检测。分析3种标本类型的病毒核酸阳性率及肛拭子病毒核酸阳性时痰液标本和咽拭子标本中 病毒核酸检出情况。结果 共收集50例COVID-19患者的156份样本，其中痰液标本41份，检出SARS-CoV-2阳性 8份（19.5%）；咽拭子标本55份，检出SARS-CoV-2阳性6份（10.9%）；肛拭子标本60份，检出SARS-CoV-2阳性11份 （18.3%）。50例COVID-19患者在恢复期出现病毒核酸阳性者痰液、咽拭子和肛拭子样本核酸检测阳性分别有8例 （19.5%）、6例（12.0%）和10例（20.0%）。10例肛拭子核酸检测阳性患者的呼吸道标本核酸检测显示9例为阴性。结 论 COVID-19患者恢复期肛拭子SARS-CoV-2核酸阳性检出率较咽拭子和痰液标本检出率稍高。患者恢复期的 呼吸道标本SARS-CoV-2核酸连续检测阴性时，应考虑添加肛拭子检测作为出院或者隔离标准。

Evaluation of SARS-COV-2 nucleic acid in convalescent anal swabs of patients with coronavirus disease 2019

Objective To analyze the detection rate and clinical value of SARS-CoV-2 nucleic acid in anal swab specimen from the convalescent patients with novel coronavirus infection (COVID-19). Methods SARS-CoV-2 nucleic acid samples were detected in convalescent patients with COVID-19 including sputum, pharyngeal swabs and anal swabs specimens. The nucleic acid positive rates of three types of specimens were analyzed. Meanwhile, the nucleic acid detection rates of sputum and pharyngeal swab specimens were analyzed in patients with the positive nucleic acid of anal swab virus. Results A total of 156 samples were collected from 50 patients with COVID 19. The positive for SARS-CoV-2 nucleic acid was 8 (19.5%) in 41 sputum samples. The positive for SARS-CoV-2 nucleic acid was 6 (10.9%) in 55 throat swab samples. The positive for SARS-CoV-2 nucleic acid was 11 (18.3%) in 60 anal swab specimen. Among the 50 convalescent patients with COVID-19, sputum, pharyngeal swabs and anal swab samples were 8 cases (19.5%), 6 cases (12.0%) and 10 cases (20.0%), respectively. In 10 patients with positive anal swab detection, 9 cases were found negative in the respiratory tract specimens. Conclusion The positive detection rate of SARS-CoV-2 nucleic acid is higher in anal swab specimen than that of laryngeal swabs and sputum specimens of the convalescent patients with COVID-19. When SARS-CoV-2 nucleic acid is negative in respiratory tract specimens, the anal swab specimen should be detected in the recovery period, which can be used as leaving hospital standard or isolation standard.