GOLPH3蛋白在新疆哈萨克族食管鳞癌中的表达及其临床意义

目的:研究GOLPH3蛋白在新疆哈萨克族（哈族）食管鳞癌中的表达及其临床意义。方法:本次研究选取50例术前未经放化疗干预且手术切除的新疆哈族食管鳞癌组织及50例哈族癌旁相对正常食管组织作为研究对象，截止日期为2018年6月，应用免疫组织化学技术，检测GOLPH3蛋白在哈族食管鳞癌组织及癌旁组织的表达特点及情况。结果:GOLPH3蛋白在哈族食管鳞癌组织的表达率为70.0%，高于癌旁正常组织28.0%，差异具有统计学意义(P=0.001)；低分化组阳性表达率82.9%高于高分化组40.0%，差异具有统计学意义(P=0.02)；淋巴结转移组阳性表达率85.3%高无淋巴结转移组37.5%，差异具有统计学意义(P=0.01)；临床分期在Ⅲ-Ⅳ组阳性表达率83.3%，高于Ⅰ-Ⅱ组的50.0%，差异具有统计学意义(P=0.012)；男性组中GOLPH3蛋白的表达阳性率为64.7%，女性组为81.3%，差异无统计学意义(P=0.234)；高龄组（≥60岁）GOLPH3蛋白的表达阳性率79.2%，低龄组（＜60岁）为61.5%，差异无统计学意义(P=0.174)。结论:GOLPH3蛋白的表达可能与哈族食管鳞癌的分化、增殖和转移等过程有关。

Expression and clinical significance of GOLPH3 protein in esophageal squamous cell carcinoma of Xinjiang Kazakh

Objective:To study the expression and clinical significance of GOLPH3 protein in Xinjiang Kazakh (ha) esophageal squamous cell carcinoma.Methods:In this study,50 cases of Xinjiang Kazakh's esophageal squamous cell carcinoma and 50 cases of Ha's cancer adjacent to normal esophageal tissue were selected as subjects before surgery.The deadline was June 2018.Immunohistochemical technique was used to detect the expression and characteristics of GOLPH3 protein in the esophageal squamous cell carcinoma and adjacent tissues of the Kazakh.Results:The expression rate of GOLPH3 protein in the esophageal squamous cell carcinoma of the Kazakh was 70.0%,which was higher than that of the adjacent normal tissues (28.0%).The difference was statistically significant (P=0.001).The positive expression rate of the poorly differentiated group was 82.9%,higher than that of the highly differentiated group (40.0%).The difference was statistically significant (P=0.02).The positive expression rate of lymph node metastasis group was 85.3% and the lymph node non-metastasis group was 37.5%.The difference was statistically significant (P=0.01).The clinical expression rate was 83.3% in group III-IV,which was higher than that in group I-II (50.0%).The difference was statistically significant (P=0.012).The positive expression rate of GOLPH3 protein in male group was 64.7% and 81.3% in the female group.The difference was not statistically significant (P=0.234).The positive rate of GOLPH3 protein expression was 79.2% in the older group (≥60 years old) and 61.5% in the younger group (<60 years old).The difference was not statistically significant(P=0.174).Conclusion:The expression of GOLPH3 protein may be related to the differentiation,proliferation and metastasis of esophageal squamous cell carcinoma of the Kazakh.