基于Oncomine数据库分析SNRPB基因在乳腺癌中的表达及临床意义

目的:研究小核糖体核蛋白B（small nuclear ribonucleoprotein polypeptides B and B1，SNRPB)在乳腺癌中的表达及临床意义。方法:运用Oncomine数据库搜索乳腺癌与SNRPB基因相关的数据，通过Kaplan-Meier Plotter数据库分析SNRPB基因与乳腺癌患者预后的关系。结果:Oncomine数据库中SNRPB基因癌组织／正常组织表达量分析结果共有414个，在癌组织中显著高表达109个，低表达3个。其中13个分析结果显示SNRPB在乳腺癌组织(包括6个侵袭性乳腺癌分析结果)中显著高表达，低表达的分析结果为1个。运用Kaplan-Meier Plotter数据库分析结果显示，高表达SNRPB的乳腺癌患者其总体生存率（OS）、无复发生存率（PFS）、无远处转移生存率（DMFS）显著低于低表达SNRPB的乳腺癌患者(P＜0.05)。结论:SNRPB基因在乳腺癌中高表达，可以作为有效的生物标志物预测乳腺癌患者转移的发生及判断预后，可为乳腺癌的靶向治疗提供依据。

Expression of SNRPB and its prognostic role in breast cancer:An analysis based on the data-mining of Oncomine

Objective:To determine the expression of SNRPB （small nuclear ribonucleoprotein polypeptides B and B1，SNRPB) in breast cancer and the relevant prognosis.Methods:Using Oncomine database to search data related to SNRPB gene in breast cancer.The relationship between SNRPB gene and prognosis of breast cancer patients was analyzed by Kaplan-Meier Plotter database.Results:The expression of SNRPB gene in tumorous and normal tissues in Oncomine database was analyzed in 414 cases and there were 109 cases with high expression and 3 cases with low expression in cancer tissues.Among them,13 analysis results showed that SNRPB was significantly overexpressed in tissues of breast cancer (including 6 invasive breast cancer tissues),and the result of low expression was 1.The results of Kaplan-Meier Plotter database analysis showed that the OS,PFS and DMFS of breast cancer with high SNRPB expression were significantly lower than those with low SNRPB expression (P＜0.05).Conclusion:SNRPB gene is highly expressed in breast cancer,which can be used as an effective biomarker to predict the occurrence of metastasis and prognosis of breast cancer patients,and provide a basis for targeted treatment of breast cancer.