凋亡相关蛋白Survivin及突变型p53在膀胱移行细胞癌中的临床意义

目的：Survivin、突变型p53在膀胱移行细胞癌（BTCC）中表达的临床意义。方法：应用SP免疫组织化学法检测60例行TUR—BT术切除BTCC标本组织石蜡切片中Survivin，突变型p53表达，结合临床资料进行分析，20例正常膀胱黏膜为对照。结果：Survivin在BTCC标本中的表达阳性率为70．0％（42／60），而正常对照组中无1例呈阳性表达；Survivin表达与BTCC的初发、复发、病理分级有显著相关（P〈0．05），但与肿瘤数目，临床分期无关（P〉0．05）；突变型p53在BTCC标本中表达阳性率为65．0％（39／60），与对照组阳性率35．0％（7／20）相比差异有统计学意义（P〈0．05），与BTCC的初发、复发、病理分级，临床分期有显著相关（P〈0．05），它与肿瘤数目无统计学意义（P〉0．05），BTCC中Survivin和突变型p53相比差异无统计学意义（P〉0．05）。结论：Survivin在膀胱移形细胞癌中高表达提示该基因在BTCC发生发展中有着重要的作用，Sur—vivin和突变型p53对临床医生判断BTCC的预后有着一定的临床指导意义。

Clinical sighificance of Survivin and p53 in bladder transitional cell carcinoma

Objective： To study clinical significancein of Survivin, p53 in bladder transitional cell carcinoma （BTCC）. Methods：The expression of Survivin was detected by immunohistochemical method in the paraffin embed-ded sections of 60 BTCC patients, 20 normal bladder tissues were used as control group. Results： The positive rate of the expression of Survivin in BTCC was 70.0% （42/60） , while none of 20 cases in control group expressed Survivin. The positive rate of the expression of Survivin was related to the recurrence and the histological grades （ P 〈 0.05 ）. It wasn＇t related to the tumor number and clinical stage. The positive rate of the expression of p53 in bladder was 65.0% （39/60） ,with mucosae 35.0% （7/20） （P 〈0.05）. It was related to the recurrence,the histological grades and clinical stage （P 〈 0.05 ）, was not related to the tumor number （ P 〉 0.05 ）. Conclusion： The expression of Survivin in BTCC is up - regulated, indicating this gene may play an important role in the process of carcinogenesis of bladder. The changes in the level of Survivin, p53 may play important roles in the prognosis.