磁化传递成像观察多发性硬化大鼠中枢神经系统病灶

目的：探索应用3.0T临床型MR设备进行磁化传递成像（MTI）观察多发性硬化（MS）大鼠中枢神经系统病灶的可行性。方法：用髓鞘少突胶质细胞糖蛋白多肽35-55（MOG35-55）致敏Lewis大鼠制备MS动物模型实验性自身免疫性脑脊髓炎（EAE）大鼠10只,正常对照组大鼠4只。3.0T临床型MR扫描仪配备小正交腕关节线圈,分别对大鼠脑和脊髓行T2W、T1磁化传递和T1非磁化传递三维容积扫描。利用工作站专业软件获得磁化传递率（MTR）图像。结果：成功建立MOG35-55-EAE模型大鼠10只。大鼠脑和脊髓的MTR图像具有较高的空间分辨率和对比度。MOG35-55-EAE病灶在T2WI上呈高信号,在MTR图像上表现为MTR值下降,呈低信号,在T1WI上呈低信号或者等信号。MTR图像对MOG35-55-EAE病灶检出率高,病灶显示清晰。对照组大鼠MR扫描未见异常。结论：应用3.0T临床型MR设备可以获得高质量的MOG35-55-EAE大鼠脑和脊髓MTR图像。MTI有望成为小动物中枢神经系统脱髓鞘疾病实验研究的体外监测手段。

Magnetization transfer imaging in the central nervous system of multiple sclerosis model rats

Objective:To investigate the intravital visibility of magnetization transfer imaging(MTI) in central nervous system lesions of multiple sclerosis(MS) model rats by using 3.0 T clinical whole body magnetic resonance-scanners.Methods:Ten healthy Lewis rats were injected with the peptide 35-55 of myelin oligodendrocyte glycoprotein(MOG35-55) to become the experimental autoimmune encephalomyelitis(EAE),the model of MS.Control group rats were four.On 3.0 T MR-scanner equipped with a quadrature wrist coil,rats we...