吲哚菁绿清除试验和终末期肝病模型评分

目的探讨吲哚菁绿(ICG)清除试验与4种终末期肝病模型评分(MELD、MELD-Na、MESO、iMELD)之间的关系。方法 70例失代偿期肝硬化患者行ICG清除试验检测15分钟滞留率(R15)和血浆清除率(K);同时计算患者MELD、MELD-Na、MESO和iMELD评分,采用Spearman等级相关性分级及LSD检验,比较ICGR15、K值与MELD、MELD-Na、MESO和iMELD评分之间的关系。结果随着Child-Pugh分级的升高,R15、MELD、MELD-Na、MESO、iMELD评分升高,K值降低。R15与MELD、MELD-Na、MESO、iMELD呈正相关(r=0.59、0.56、0.61、0.63,P<0.05),K值与MELD、MELD-Na、MESO、iMELD评分呈负相关(r=-0.55、-0.53、-0.58、-0.59,均P<0.05)。结论 R15和K值与MELD、MELD-Na、MESO、iMELD评分关系密切;R15与4种终末期肝病模型评分相关性比K值显著,其中R15与iMELD相关性更加显著。

Indocyanine green clearance test and model for end-stage liver disease scores

Objective To investigate the correlation among indocyanine green(ICG) clearance test and model for end-stage liver disease scores including MELD,MELD-Na,MESO and iMELD scores.Methods Seventy patients with decompensated liver cirrhosis were selected.The ICG clearance test(K value and R15) was performed,and the MELD,MELD-Na,MESO,iMELD scores of patients with decompensated liver cirrhosis were calculated.Results As the Child-Pugh classification of liver function gradually deteriorated,R15 and MELD,MELD-Na,MESO,iMELD scores increased,while K value decreased,significant statistical differences in K value,R15,MELD,MELD-Na,MESO,iMELD scores were found between patients with different Child-Pugh classifications.Significant correlations were found among the parameters of the ICG clearance test(K value and R15)) and MELD,MELD-Na,MESO,iMELD scores.The positive correlation was observed among R15 and MELD,MELD-Na,MESO,iMELD scores(r=0.59,0.56,0.61,0.63;P<0.05),while the negtive correlation were observed among K value and MELD,MELD-Na,MESO,iMELD scores(r=-0.55,-0.53,-0.58,-0.59;P<0.05).Conclusion K value and R15 have significant correlation with MELD,MELD-Na,MESO,iMELD score,especially the R15,and R15 has the best significant correlation with iMELD in four model for end-stage liver disease scores,which may be convenient and appropriate indicator to evaluate liver function of patients with decompensated liver cirrhosis,and better than MELD score.