冠心病患者纤维蛋白原、超敏C反应蛋白及总胆红素检测的意义

目的:探讨纤维蛋白原(Fg)、超敏C反应蛋白(hs-CRP)和总胆红素(TBIL)水平与冠心病的关系。方法:选择200例冠心病患者及200例健康对照者,进行Fg、hs-CRP和血清TBIL的定量测定。结果:与健康对照组比较,冠心病组Fg(2.75±0.97)g/L∶(4.51±0.42)g/L]、hs-CRP(1.64±0.57)mg/L∶(5.31±1.91)mg/L]水平明显升高(P均0.05),而血清TBIL(26.71±3.72)μmol/L∶(14.26±2.44)μmol/L]水平明显降低(P0.01);按陈旧性心肌梗塞组、稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗塞组的排列顺序,血浆hs-CRP和Fg水平呈上升趋势,而TBIL水平呈下降趋势,组间差异显著(P0.05~0.01)。结论:冠心病患者血液中存在高纤维蛋白原、超敏C反应蛋白和低总胆红素的现象,以急性心肌梗塞患者最为突出,提示纤维蛋白原和超敏C反应蛋白水平升高,总胆红素水平降低可能是冠心病发生、发展的重要危险因素之一。

Significance detecting fibrinogen,high sensitive C-reactive protein and total bilirubin for the patients with coronary heart disease

Objective： To investigate the relationship among fibrinogen, high sensitive C-reactive protein （hs-CRP）, total bilirubin levels and coronary heart disease. Methods： The plasma fibrinogen, hs-CRP and serum total bilirubin were quantitative detected for 200 patients with coronary heart disease （CHD group） which were divided into four subgroups old myocardial infarction （OMI）, stable angina pectoris （SAP）, unstable angina pectoris （UAP）, and acute myocardial infarction （AMI）] and 200 subjects as healthy control group. Results： The average plasma fibrinogen, hs -CRP levels of CHD group were significantly higher than those of healthy control group fibrinogen （4.51±0.42） g/Lvs. （2.75±0.97） g/L, hs-CRP （5.31±1.91） mg/L vs. （1.64±0.57） mg/L, P〈0.05, respectively], while the average serum total bilirubin levels was significantly lower than that of healthy control group （14.26 ±2.44） μmol/L vs. （26.7±53.72） μmol/L , P〈0.01]. It was observed that fibrinogen and hs-CRP levels increased and the total bilirubin level decreased in four subgroups （according OMI, SAP, UAP, AMI order） of CHD （P〈0.05- 0.01, compared between groups one by one）. Conclusion： High concentrations of plasma fibrinogen and hs- CRP, but low concentration of serum total bilirubin are in patients with coronary heart disease, especially in acute myocardial infarction, suggest that those are important risk factors for the occurring and developing of coronary heart disease.