卡维地洛固体分散体的制备及其体外溶出度的测定

目的 :制备卡维地洛固体分散体 ,提高其溶解度和溶速率。方法 :以聚乙烯吡咯烷酮 (PVP)、聚乙二醇 -6000(PEG -6000)为载体 ,以溶剂法和熔融法制备固体分散体 ,并进行体外溶出度研究。结果 :载体比例越大 ,药物溶出愈快 ;载体比例愈小 ,差异愈显著。载体为PVP所制固体分散体的体外溶出行为总体优于载体为PEG -6000的固体分散体。结论 :本试验所制卡维地洛固体分散体能加速体外溶出 ,提高生物利用度 ,可用于制备高效制剂

Preparation and In Vitro Dissolubility of Carvedilol Solid Dispersion

OBJECTIVE:To improve the dissolubility and dissolution rate of carvedilol.METHODS:Carvedilol solid dispersions were prepared using solvent-melting and coevaporation methods with PEG-6000 and PVP as carriers and in vitro dissolubility was studied in simulated gastric juice.RESULTS:The results of in vitro dissolubility test showed that the higher the carrier-car ratio,the faster the drug dissolution.The in vitro dissolubility of solid dispersions with PVP as carrier was faster than that of solid dispersions with PEG-6000 as carrier.CONCLUSION:Accelerating the rate of in vitro release and improving bioavailability,carvedilol solid dispersion was a promising preparation.