| 复方地黄对AD大鼠脑组织中MAO、GS、r—GT活力的影响 |
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| 引用本文： | 侯金才,张翠香,廉洁,周丽,陆佰荣,孙丽慧.复方地黄对AD大鼠脑组织中MAO、GS、r—GT活力的影响[J].齐齐哈尔医学院学报,2004,25(8):844-846. |
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| 作者姓名： | 侯金才 张翠香 廉洁 周丽 陆佰荣 孙丽慧 |
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| 作者单位： | 齐齐哈尔医学院,161042 |
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| 摘 要： | 目的研究复方地黄对AD大鼠脑组奴中MAO、GS、r—GT活力的影响。方法D-丰乳糖皮下注射8周拟衰老，然后喹啉酸(QA)海马CA1区定位注射制作AD模型；用复方地黄治疗，西药对照给予脑复康；采用Morris水迷宫法测试行为学；检测脑组织中单氨氧化酶MAO、谷氨酰胺合成酶GS、r-L-谷氨酰转肤酶r—GT活力变化。结果两治疗组大鼠空间记忆能力较模型组大鼠有明显改善，两治疗组r—GT活力明显下降，GS活力明显升高，MAO活力也相应提高。结论治疗AD大鼠复方地黄有明显的疗效。
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| 关 键 词： | 复方地黄 老年性痴呆 单氨氧化酶 谷氨酰胺合成 r-L-谷氨酰转肤酶 |
Influence of Compound Dihuang on the Activities of MAO, GS, r-GT in the Brain Tissue of AD Rats |
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| Hou Jincai,et al..Influence of Compound Dihuang on the Activities of MAO, GS, r-GT in the Brain Tissue of AD Rats[J].Journal of Qiqihar Medical College,2004,25(8):844-846. |
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| Authors: | Hou Jincai |
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| Abstract: | Objective To explore the influence of compound DiHuang on the activities of MAO, GS, r-GT in the brain tissue of AD model rats. Methods Using D-galactose to accelerate aging process and quinolinic acid to damage neurons of hippocampal gyrus in rats to obtain AD-model-rats, the compound DiHuang was used in the experiment group, meanwhile comparing with Naofukang capsule in the control group. The levels of MAO?GS and r-GT in the serum were measured.Results Compound DiHuang can shorten the AD-rat incubation period in Morris water labyrinth comparing with the control, the activity of GS and MAO increased markedly, the activity of r-GT was decreased. Conclusions The compound DiHuang can improve pathology changes of AD-rat's brain. |
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| Keywords: | Alzheimer's disease Compound Dihuany MAO GS r-GT |
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