三聚氰胺泌尿系结石住院婴幼儿一年后随访结果分析

目的 了解2008年喂养三聚氰胺污染奶粉1年后对婴幼儿泌尿系发育的影响.方法 选取178例,随访时年龄:(29.3±9.6)个月,曾住院治疗的三聚氰胺泌尿系结石(MUS)婴幼儿进行16个月随访.随访内容包括泌尿系超声、尿、血常规和肾功能检查及疗效.选取同期非纯母乳和无三聚氰胺污染奶粉喂养史正常儿童110例为对照组(CG),年龄:(29.6±10.1)个月,比较两组相关参数异同.结果 161例成功随访;89例带石出院患儿院外行保守治疗,随访时56例结石消失,25例变小,7例无明显变化,1例增大.MUS患儿补钙的比例明显低于CG、身高偏低的比例显著高于CG(P<0.05).随访未发现泌尿系占位病变.尿常规、血常规无异常,肾和膀胱功能及形态均未见明显异常.结论 食用三聚氰胺污染奶粉1年后对婴幼儿身体和泌尿系发育未产生明显影响.

One year clinical follow-up of the infants and young children with Melamine-related urinary stones

Objective To present the results of 1 year follow-up of infants and young children with melamine-related urinary stones (MUS).Methods The clinical data of the 1 year follow-up of the 178 infants and young children with an average age of 29.3± 9.6 months old were retrospectively reviewed.The MUS were formed by melamine-tainted milk feeding.Their urinary tract ultrasonographies,urinalysis results and renal function values were followed up for a year.One hundred and ten age (age,29.6 ± 10.1 months)and gender matched health individuals were taken as controls.Results Eighty-nine children had residual MUS at the time of discharge.After 1 year follow-up,56 patients'MUS disappeared completely;25 patients' MUS partially dissolved;1 patient's MUS enlarged;and 7patients' MUS remained the same size.No tumors were detected.Routine blood tests,renal and bladder function as well as urinalysis were normal.The incidence of under-height MUS infants was significantly higher compared to that of the controls (P<0.05).Furthermore,the proportion of MUS infants with calcium supplementation was significantly lower compared to that of the controls (P<0.05).Conclusions MUS patients have normal kidney function and body growth.