Sildenafil attenuates pulmonary arterial pressure but does not improve oxygenation during ARDS期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Sildenafil attenuates pulmonary arterial pressure but does not improve oxygenation during ARDS

Authors:	Alexander D Cornet Jorrit J Hofstra Eleonora L Swart Armand R J Girbes Nicole P Juffermans

Affiliation:	(1) Department of Intensive Care, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands;(2) Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands;(3) Department of Anaesthesiology, Academic Medical Center, Amsterdam, The Netherlands;(4) Department of Clinical Pharmacology and Pharmacy, VU University Medical Center, Amsterdam, The Netherlands

Abstract:	Objective Pulmonary hypertension is a characteristic feature of acute respiratory distress syndrome (ARDS) and contributes to mortality. Administration of sildenafil in ambulatory patients with pulmonary hypertension improves oxygenation and ameliorates pulmonary hypertension. Our aim was to determine whether sildenafil is beneficial for patients with ARDS.

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