| Effect of Cerium on Expression and Activity of MMP-9 from Human Carcinoma of Bladder Cell Line |
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| 作者姓名： | 李瑾 胡国武 欧阳砥 牛瑞芳 周永洽 申泮文 |
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| 作者单位： | Department of Chemistry，Nankai University，Tianjin 300071，China，Department of Chemistry，Nankai University，Tianjin 300071，China，Department of Chemistry，Nankai University，Tianjin 300071，China，Central Laboratory，Tianjin (Cancer) Hospital，Tianjin 300060，China，Department of Chemistry，Nankai University，Tianjin 300071，China，Department of Chemistry，Nankai University，Tianjin 300071，China |
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| 基金项目： | ProjectsupportedbyStateKeyProjectofFundamentalResearch ( 96-90 6-0 1-13 ) |
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| 摘 要： | Rareearthshaveledtowidespreadinterestsinlifescience ,whilethescientistsdoresearchesdeeplyinmedicalandbiochemicalfields .Rareearthsplaypotentialrolesininhibitingcancer ,andalargenum berofscientistsdedicatethemselvestoit1] .Thema trixmetalloproteinases (MMPs)areafamilyofatleast1 7humanzinc dependentendopeptidasesthatareca pableofdegradingalmostallextracellularmatrix(ECM)components .Theyareessentialinmanyphys iologicalprocessesandseveralpathologicalconditions ,suchastumorprogression .MMPsare…
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| 关 键 词： | 细胞生物学 膀胱癌 铈 生物活性 比色法 |
Effect of Cerium on Expression and Activity of MMP-9 from Human Carcinoma of Bladder Cell Line |
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| Li Jin ,Hu Guowu ,Ou Yangdi ,Niu Ruifang ,Zhou Yongqia ,Shen Panwen.Effect of Cerium on Expression and Activity of MMP-9 from Human Carcinoma of Bladder Cell Line[J].Journal of Rare Earths,2004,22(2):288-291. |
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| Authors: | Li Jin Hu Guowu Ou Yangdi Niu Ruifang Zhou Yongqia Shen Panwen |
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| Affiliation: | Li Jin 1,Hu Guowu 1,Ou Yangdi 1,Niu Ruifang 2,Zhou Yongqia 1*,Shen Panwen 1 |
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| Abstract: | The effects of Ce4 on cell survival,expression and activity of matrix metalloproteinase-9(MMP-9)with MTT colorimetry and gelatin zymography assays in human bladder carcinoma cell line was studied.The results indicate that the lower concentration of Ce4 (0.01 mmol*L-1)has no influence on cell growth,but inhibits extremely expression of MMP-9 and increases its activity,whereas the higher concentration of Ce4 (1.0 mmol*L-1)can inhibit all of them.The results raise the possibility that Ce4 may have beneficial effects in attenuating invasion and metastasis of malignant tumors. |
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| Keywords: | cytobiology cerium matrix metalloproteinases malignant tumor metastasis rare earths |
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