艾滋病合并马尔尼菲青霉菌病120例实验室结果分析

目的探讨艾滋病（AIDS）合并马尔尼菲青霉菌病（PSM）患者的实验室检测结果特点,为临床诊断提供可靠依据,达到早期诊断和早期治疗的目的。方法对120例艾滋病合并马尔尼菲青霉菌病患者的实验室资料进行分析。结果艾滋病合并马尔尼菲青霉菌病患者易发生机会性感染,常见病原体依次为真菌、细菌、病毒;血常规血红蛋白偏低,女性100%贫血,男性71.7%贫血;白细胞较低,平均值为5.6×10^9/L,〈4×10^9/L占50%（60/120）;流式细胞计数CD4＋细胞明显降低,平均值为26×10^6/L,〈50×10^6/L占88.3%（106/120）。被调查病例中CD4＋细胞〈50×10^6/L时,易发生病原微生物机会性感染。结论大多数艾滋病合并马尔尼菲青霉菌病患者,CD4＋细胞明显降低,出现不同程度的贫血和白细胞降低,常发生机会性感染,常出现两种或多种病原体合并感染,病原体依次为真菌、细菌、病毒。

Laboratory analysis of 120 AIDS cases complicated with Penicillium marneffei

Objective To analyze the laboratory indicators of AIDS patients complicated with Penicillium marneffei（PSM） and provide reliable evidence for early clinical diagnosis and treatment. Methods The laboratory data of 120 AIDS cases complicated with Penicillium marneffei were analyzed. Results The results have showed that AIDS patients complicated with Penicillium marneffei were susceptible to opportunistic infections,and the common pathogens were fungi,bacteria and viruses; the Hb in routine blood test was low,anemia in women was 100% and in men was 71.7%; WBC was relatively low with the average value of 5.6 × 109 / L,and the cases with WBC below 4 × 109 / L accounted for 50% （60/120）; flow cytometry CD＋4cells decreased significantly,with an average of 26 × 106 / L,and the cases with a value below 50 × 10^6 / L accounted for 88.3 % （106/120）; those cases whose CD＋4 cells were less than 50 × 10^6 / L were susceptable to opportunistic infections and pathogenic microorganisms. Conclusion In most AIDS cases complicated with Penicillium marneffei,CD＋4 cells evidently decrease,anemia and leukocytopenia are present to various extents; opportunistic infections often occur with 2 or more pathogens,commonly fungi,bacteria and viruses.