| 复方新霉素溶液中地塞米松磷酸钠含量测定的考察 |
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| 引用本文： | 蔡建华,陈珊珊,范丽丽.复方新霉素溶液中地塞米松磷酸钠含量测定的考察[J].海峡药学,2010,22(10):62-64. |
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| 作者姓名： | 蔡建华 陈珊珊 范丽丽 |
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| 作者单位： | 1. 福建莆田市药品检验所,莆田,351100
2. 福建莆田学院,莆田,351100 |
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| 摘 要： | 目的通过建立HPLC法测定复方新霉素溶液中地塞米松磷酸钠的含量。方法采用高效液相色谱法,色谱柱：kromasil-C18（250mm×4.6mm,5μm）;流动相：甲醇-0.34%磷酸二氢钾溶液（60∶40）;检测波长：242nm;柱温：20℃;流速：0.7mL.min^-1。结果地塞米松磷酸钠的含量在0.4128-2.0640μg范围内线性关系良好。回归方程：Y=2×10^6X-11264,r=0.9999,加样回收率平均值为100.2%。结论本方法快速、结果准确,可用于质量控制。
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| 关 键 词： | 复方新霉素溶液 地塞米松磷酸钠 HPLC |
Determinate the content of dexmethasone sodium phosphate in compound prescirption neomycin solution |
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| CAI Jian-hua,CHEN Shan-shan,FAN Lili.Determinate the content of dexmethasone sodium phosphate in compound prescirption neomycin solution[J].Strait Pharmaceutical Journal,2010,22(10):62-64. |
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| Authors: | CAI Jian-hua CHEN Shan-shan FAN Lili |
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| Affiliation: | 1.Putian institute for drug control,Putian 351100,China;2.Putian University,Putian 351100,China) |
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| Abstract: | OBJVECTIVE To establish a HPLC method for determination the content of Dexamethasone Sodium Phosphate in compound Prescirption Neomycin solution.METHODS The high-performance liquid chromatography,Column：kromasil-C18（250mm×4.6mm,5μm）,Mobile phase：methanol0.34% KH2PO4 solution（60∶40）;Detection wavelength：242nm;The temper of oven：20℃;Flow rate：0.7mL·min^-1.Results：the content of Dexamethasone Sodium Phosphate in range of 0.4128～2.0640μg a good linear relationship.The regression equation：Y=2×10^6X-11264,r=0.9999,Recoveries averaged is 100.2%.CONCLUSION The HPLC method is quick and accurate,can be used for the quality control. |
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| Keywords: | HPLC |
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