乙酰半胱氨酸预防肺癌放射性肺损伤的效果观察

目的 观察乙酰半胱氨酸对肺癌放射性肺损伤的预防作用.方法 80例不能手术的非小细胞肺癌患者随机分成两组,采用体部伽玛刀立体定向三维适形放射技术,总剂量65～75 Gy.治疗组伽玛刀放疗同时联合应用乙酰半胱氨酸,对照组单纯予以伽玛刀放疗.结果 80例患者全部完成放疗计划,有效率( CR+ PR)治疗组为90％,对照组为85％,两组差异无统计学意义(x2=0.114,P＞0.05).急性放射性肺损伤和晚期肺纤维化发生率治疗组为15％和20％,对照组为33％和45％,两组差异均有统计学意义(均P＜0.05).结论 接受放射治疗的非小细胞肺癌患者应用乙酰半胱氨酸对放射性肺损伤的发生有一定的预防作用,而不影响放疗效果.

Observation on protective effect of acetylcysteine on radiation pneumonitis

Objective To observe the protective effect of acetyleysteine against radiation pneumonia.Methods Total of 80 patients who were inoperable were randomly allocated into treatment group and control group. Using conformal radiation technology and the total dose was 65 - 75Gy. The patients in treatment group were given acetylcysteine and radiotherapy;the patients in control group were given radiotherapy only. Results All patients were treated radiotherapy. The effective rate（ CR and PR） of treatment group was 90% ,and that of control group was 85% （P 〉0. 05 ）;The incidence of acute radiation pneumonia and pulmonary fibrosis in treatment group were 15% and 20% ,respectively;and that of control group were 33% and 45% respectively. There was significant difference between the two groups （ P 〈 0. 05 ）. Conclusion Using acetyleysteine during radiotherapy could prevent radiation pneumonia in the non-small cell lung cancer patients.