| 1,3,4-噻二唑取代的N-(噻吩并吡啶)乙酰胺类化合物的合成及生物活性研究 |
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| 引用本文： | 周炳森,欧阳贵平,孔欣欣,郭正美,贺宝安,黎世泽.1,3,4-噻二唑取代的N-(噻吩并吡啶)乙酰胺类化合物的合成及生物活性研究[J].现代农药,2013(6):8-12. |
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| 作者姓名： | 周炳森 欧阳贵平 孔欣欣 郭正美 贺宝安 黎世泽 |
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| 作者单位： | 贵州大学精细化工研究开发中,教育部绿色农药与农业生物工程重点实验室,贵阳550025 |
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| 基金项目： | 贵州大学引进人才科研基金[贵大人基合字（2008）040号]资助项目 |
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| 摘 要： | 以2-氯-3-氰基吡啶为起始原料,设计并合成了一系列1,3,4-噻二唑取代的N-(噻吩并吡啶)乙酰胺类新化合物。所有化合物或中间体结构经1H NMR、13C NMR、IR和MS确认。初步生物活性测试结果表明,部分化合物具有较高的抑菌或杀虫活性。
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| 关 键 词： | (噻吩并吡啶)乙酰胺 1 3 4-噻二唑 合成 生物活性 |
Synthesis and Biological Activities of N-（thieno[2,3-b]pyridin-3-yl）acetamide Compounds with Substituent of 1,3,4-Thiadiazole |
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| ZHOU Bing-sen,OUYANG Gui-ping,KONG Xin-xin,GUO Zheng-mei,HE Bao-an,LI Shi-ze.Synthesis and Biological Activities of N-（thieno[2,3-b]pyridin-3-yl）acetamide Compounds with Substituent of 1,3,4-Thiadiazole[J].Modern Agrochemicals,2013(6):8-12. |
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| Authors: | ZHOU Bing-sen OUYANG Gui-ping KONG Xin-xin GUO Zheng-mei HE Bao-an LI Shi-ze |
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| Affiliation: | (Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Research and Development Center of Fine Chemicals, Guizhou University, Guiyang 550025, China) |
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| Abstract: | A series of novel N-（thieno2,3-b]pyridin-3-yl）acetamide compounds with substituent of 1,3,4-thiadiazole were designed and synthesized starting from 2-chloronicotinonitrile.The structures of all target compounds or intermediates were confirmed by1H NMR,13C NMR,IR and MS.The preliminary bioassay results showed that some of the compounds exhibited antifungal insecticidal activities. |
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| Keywords: | （thieno[2 3-b]pyridin-3-yl）acetamide 1 3 4-thiadiazole synthesis bioactivity |
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