| 川芎挥发油对发热大鼠下丘脑环氧化化酶-2蛋白表达的影响 |
| |
| 引用本文： | 杨金蓉,宋军,胡荣,李祖伦,张权森.川芎挥发油对发热大鼠下丘脑环氧化化酶-2蛋白表达的影响[J].成都中医药大学学报,2008,31(3):38-39. |
| |
| 作者姓名： | 杨金蓉 宋军 胡荣 李祖伦 张权森 |
| |
| 作者单位： | 成都中医药大学,四川,成都,610072;四川省中医药科学院,四川,成都,610041 |
| |
| 基金项目： | 四川省科技厅资助项目，四川省教育厅资助项目 |
| |
| 摘 要： | 目的:探讨川芎挥发油解热作用机理.方法:采用免疫组化方法研究川芎挥发油对啤酒酵母发热大鼠下丘脑组织COX-2蛋白表达的影响.结果:模型组大鼠下丘脑COX-2蛋白表达高于正常对照组(P<0.01),川芎挥发油高、中剂量组COX-2蛋白表达低于模型组(P<0.01或0.05),低剂量组与模型组相比无明显差异(P>0.05).结论:川芎挥发油解热机理之一可能是抑制大鼠下丘脑COX-2的表达从而减少PGE2的产生使中枢体温调定点下调达解热效应.
|
| 关 键 词： | 川芎挥发油 COX-2 表达 |
Essential Oil of Ligusticum Chuanxiong Hort's Influence on Expressions of COX-2 in Hypothalamus of Fever Rat |
| |
| YANG Jin-rong,SONG Jun,HU Rong,et al.Essential Oil of Ligusticum Chuanxiong Hort's Influence on Expressions of COX-2 in Hypothalamus of Fever Rat[J].Journal of Chengdu University of Traditional Chinese Medicine,2008,31(3):38-39. |
| |
| Authors: | YANG Jin-rong SONG Jun HU Rong |
| |
| Affiliation: | YANG Jin-rong,SONG Jun,HU Rong,et al(1.Chengdu University of Traditonal Chinese Medcine,Chengdu,610072,2.Sichuan Academy of Chinese Medicine Sciences,610051) |
| |
| Abstract: | Objective: to investigate the antipyretic mechanism of Essential oil of Ligusticum chuanxiong Hort(CH).Methods:The expressions of COX-2 protein in hypothalamus of brewer's yeast-induced fever rats were checked using Immunohistochemistry.ResuLts: The expressions of COX-2 protein in hypothalamus of model team are higher than normal team,expressions of teams of high and middle dose of CH are lower than model team,expression of team of low dose of CH has no obvious different with model team.Conclusion: one of t... |
| |
| Keywords: | COX-2 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
