Phenolic composition,enzyme inhibitory,and antioxidant activity of <Emphasis Type="Italic">Bituminaria bituminosa</Emphasis> |
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Authors: | Cengiz Sarikurkcu Mustafa Cengiz Mehmet Cemil Uren Olcay Ceylan Tuba Orenc Bektas Tepe |
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Affiliation: | 1.Faculty of Pharmacy, Department of Analytical Chemistry,Süleyman Demirel University,Isparta,Turkey;2.Faculty of Science and Literature, Department of Chemistry,Süleyman Demirel University,Isparta,Turkey;3.Department of Medicinal and Aromatic Plants,Süleyman Demirel University, Atabey Vocational School,Isparta,Turkey;4.Department of Biology,Mugla Sitki Kocman University, Faculty of Science,Mugla,Turkey;5.Department of Molecular Biology and Genetics,Kilis 7 Aralik University, Faculty of Science and Literature,Kilis,Turkey |
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Abstract: | This study aimed to evaluate the in vitro antioxidant and enzyme inhibitory activities of ethyl acetate, methanol, and water extracts of Bituminaria bituminosa. In phosphomolybdenum assay, the methanol extract showed the highest activity (166.78 μmol TEs/g dry plant). The water extract exhibited the highest scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH?) and 2,2-azino-bis (3-ethylbenzothiazloine-6-sulphonic acid) (ABTS?+). In addition, it exhibited the highest activity in cupric ion reducing (CUPRAC) and ferric reducing antioxidant power (FRAP) assays (41.26 and 46.82 μmol TEs/g dry plant). The extracts did not show cholinesterase and tyrosinase inhibitory activity. However, α-glucosidase inhibition assay resulted in the superiority of water extract (1233.86 μmol ACEs/g dry plant). In the case of α-amylase inhibitory assay, the ethyl acetate extract showed the highest activity (53.65 μmol ACEs/g dry plant). The water extract exhibited the highest phenolic content (31.70 μmol GAEs/g dry plant). In contrast, the methanol extract was found rich in flavonoid compounds (5.29 μmol REs/g dry plant). The water extract contained considerable amounts of rosmarinic acid, luteolin, quercetin, and rutin. Therefore, it can be used as a source of new and alternative antioxidant and enzyme inhibitory agents. |
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