The NHCs-mediated cross-coupling of aromatic aldehydes with benzyl halides: synthesis of α-aryl ketones |
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| Authors: | Lu Lin Wei-Ping Deng |
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| Affiliation: | School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China |
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| Abstract: | A new NHCs-mediated synthetic method was found to produce α-aryl ketones in 22-63% yields in one-pot process from the corresponding aromatic aldehydes and benzyl halides. This method is the first example of the NHCs-mediated intermolecular nucleophilic acylation of aromatic aldehydes with benzyl halides. |
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