| 瘦素与儿童肥胖研究进展 |
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| 引用本文： | 孟扬,汪俊军.瘦素与儿童肥胖研究进展[J].医学研究生学报,2008,21(11). |
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| 作者姓名： | 孟扬 汪俊军 |
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| 作者单位： | 南京军区南京总医院解放军临床检验医学研究所,江苏南京,210002 |
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| 基金项目： | 国家自然科学基金资助项目，江苏省自然科学基金青年科技创新人才资助项目 |
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| 摘 要： | 瘦素(leptin)是一种主要由脂肪组织产生的蛋白激素,直接作用于下丘脑,参与能量平衡的调节,在机体肥胖的产生过程中起着重要作用.体内存在多种瘦素蛋白受体亚型,其中可溶性的瘦素受体(sOb-R)可调节瘦素水平,具有很高的检测价值.相关研究显示,瘦素很有可能成为判断儿童肥胖风险的标记物,瘦素水平还可被用来评估肥胖儿童对运动干预的应答性.
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| 关 键 词： | 瘦素 儿童肥胖 瘦素受体 |
Progress in the study of leptin and childhood obesity |
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| MENG Yang,WANG Jun-jun.Progress in the study of leptin and childhood obesity[J].Bulletin of Medical Postgraduate,2008,21(11). |
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| Authors: | MENG Yang WANG Jun-jun |
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| Affiliation: | MENG Yang reviewing,WANG Jun-jun checking(PLA Institute of Clinical Laboratory Medicine,Nanjing General Hospital of Nanjing Military Comm,,PLA,Nanjing 210002,Jiangsu,China) |
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| Abstract: | Leptin,a proteohormone primarily made by adipocytes,directly interacts with the hypothalamus for energy balance regulation.It plays an important role in the morbility of obesity.The soluble leptin receptor(sOb-R) is one of the leptin receptor isoforms.The examination of the sOb-R concentration is valuable because of its function in the regulation of leptin concentration.Leptin shows a great potential as a childhood obesity biomarker,and its concentration could be used in assessing the responsiveness of obes... |
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| Keywords: | Leptin Childhood obesity Leptin receptor |
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