早期应用尼莫地平对高血压性脑室出血患者中枢性发热的干预作用

目的 探讨早期应用尼莫地平对高血压性脑室出血患者中枢性发热的干预作用.方法 选择我科2008年2月至2010年7月收治的经确诊为高血压性脑室出血的病例46例,并随机分为实验组(实施尼莫地平治疗)及对照组(不实施尼莫地平治疗)各23例,随访1个月后,比较两组患者并发中枢性发热病例的分布差异.结果 随访1个月,无中途退出病例,其中,实验组并发中枢性发热13例(高热3例,中低热10例),无死亡病例；对照组并发中枢性发热15例(高热10例,中低热5例),死亡1例.两组患者中枢性发热病例的分布差异无统计学意义(x2=0.807,P=0.369＞0.05),而中枢性高热病例的分布差异则具有统计学意义(x2=3.939,P=0.047＜0.05).结论 早期应用尼莫地平可降低高血压性脑室出血并发中枢性发热患者的发热程度,可能对于改善该类患者的预后具有肯定意义.

Intervention effect of nimodipine in the treatment of patients both with hypertensive ventricular hemorrhage and central fever in early stage

Objective To explore the effect of nimodipine on treating patients both with hypertensive ventricular hemorrhage and central fever in the early stage. Methods Forty-six patients with hypertensive ventricular hemorrhage from Feb.2008 to Jul. 2010 were selected and randomly divided into experimental group (23 cases, treated with nimodipine) and controlled group (23 cases, treated with nimodipine). Distribution of patients with central fever was compared in both groups after following up for 1 month. Results After following up for 1 month, 13 patients were found with central fever and 3 with hyperpyrexia, 10 with mild-moderate fever in the experimental group, but in the controlled group, 15 patients were found with central fever and 10 with hyperpyrexia, 5 with mild-moderate fever. There was no dead case in the experimental group but 1 case in the controlled group. The distribution of patients with central fever in both groups has no statistical significance (χ2=0.807, P=0.369), but when compared with the distribution of patients with central high fever, statistical significance was found in the two groups (χ2=3.939, P=0.047), and the controlled group seemed to have less patients with central high fever. Conclusion Nimodipine can reduce the level of fever for patients both with hypertensive ventricular hemorrhage and central fever in the early stage,which may do good for the prognosis.