遗传性易栓症相关抗凝因子的研究进展

易栓症可定义为血栓形成的倾向性增高,主要由于凝血系统和抗凝血系统两方面因素造成。易栓症分为遗传性易栓症与获得性易栓症。现就遗传性易栓症的相关抗凝因子进行研究,从分子生物学水平上对抗凝血酶Ⅲ(AT-Ⅲ)、蛋白C(PC)、蛋白S(PS)缺陷的病理机制、疾病的诊断及其相应的实验室检查予以综述。同时,结合近年来相关国内外研究报道提出两个观点:①遗传性AT-Ⅲ、PC、PS缺陷在东西方人群的分布可能存在较大差异;②遗传性易栓症患者中存在联合缺陷。

Research Progress of the Genetic Thrombophilia Anticoagulant

Thrombophilia can be defined as increased tendency to thrombosis,mainly caused by the coagulation system and anticoagulation system.Thrombophilia is categorized into genetic thrombophilia and acquired thrombophilia.Here is to make a review on genetic thrombophilia factor for anticoagulant-related research,focusing on molecular biology level pathological mechanisms,diagnosis and appropriate laboratory tests of thrombin Ⅲ(antithrombin Ⅲ,AT-Ⅲ),and protein C(protein C,PC),protein S(protein S,PS) defects.Two points put forward according to recent domestic and foreign studes are:①Hereditary AT-Ⅲ,PC,PS deficiencies distribution in the east and west population may be quite different;②patients with hereditary thrombophilia defects have joint defects.