| 兰索拉唑与H2受体拮抗剂治疗消化性溃疡疗效对照研究的Meta分析 |
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| 引用本文： | 刘锐锋,李元文.兰索拉唑与H2受体拮抗剂治疗消化性溃疡疗效对照研究的Meta分析[J].中国中医药咨讯,2011,3(17):44-45. |
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| 作者姓名： | 刘锐锋 李元文 |
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| 作者单位： | 1. 广东省中山市人民医院药学部,广东中山,528403
2. 广东医学院2010届,广东东莞,523808 |
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| 摘 要： | 目的：探讨兰索拉唑（1ansopnzole）与H2受体拮抗剂治疗消化性溃疡疗效的差异。方法：应用Meta分析对9项研究消化性溃疡的效果进行同质性检验和合并效应量的估计。结果：（1）同质性检验：χ^2=6．5，自由度8，P〉0．05。（2）合并效应量的估计：OR合并95％可信区间为3．07—8．78。OR合并的检验：χ^2=37．7，P〈0．01。结论：兰索拉唑治疗消化性溃疡的疗效优于目前常用的H2受体拮抗剂，兰索拉唑在治疗消化道溃疡疗效方面较其他已上市的H2受体拮抗剂都要好，且不良反应较少，值得临床推广。
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| 关 键 词： | 兰索拉唑 消化性溃疡 Meta分析 质子泵 H2受体拮抗剂 |
Meta-analysis of effectiveness of lansoprazole and histamine H2 antagonists in treatment of active peptic ulcer and bleeding |
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| LIU Ruifeng,LI Yuanwen.Meta-analysis of effectiveness of lansoprazole and histamine H2 antagonists in treatment of active peptic ulcer and bleeding[J].Journal of China Traditional Chinese Medicine Information,2011,3(17):44-45. |
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| Authors: | LIU Ruifeng LI Yuanwen |
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| Affiliation: | ( Zhongshan People＇ s Hospital in Guangdong Province Zhongshan 528403 ) |
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| Abstract: | AIM： To explore the difference of efficacy between lansoprazole and histamine H2 antagonists in treatment of active peptic ulcer and bleeding. METHODS： The efficacy of lansoprazole or histamine H2 antagonists in treatment of active peptic ulcer and bleeding was analyzed by Meta-analysis in homogeneity test and combined test in 9 studies. RESULTS： Hgmogeneity test showed that the cited studies were homogeneous with χ^2=6.5,P〈0.01; and in combined test, the combined OR=5.19 and its 95% confidence interval Was in 3.07-8.78（χ^2=37.7,P〈0.01）.CONCLUSION： lansoprazole is a very effective and well-tolerated proton pump inhibitor and it is worth of being recommended for administration in patient＇ s wit active peptic ulcer and bleeding. |
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| Keywords: | lansoprazole peptic ulcer hemorrhage histamine H2 antagonists Meta-analysis proton pumps |
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