炎性线状疣状表皮痣1家系

先证者女,1岁,左侧上下肢分布红色斑丘疹伴瘙痒1年。患者出生10 d后发现左下肢可见散在分布红色斑丘疹,后逐渐增多至左侧上下肢、会阴部,呈线性分布,伴有明显瘙痒。患者外祖母及母亲均有类似皮疹,无银屑病家族史。体检未见其他异常。皮肤科情况:左足背、足底、左足大拇指、左足第四拇指与第五拇指之间、左侧腘窝、左侧会阴部及腹股沟、左手第四指与第五指之间散在的线状鳞状红斑丘疹,部分指甲受累。左足组织病理示:角化过度伴局灶角化不全,棘皮症,表皮突延长,乳头瘤状增生,真皮浅层及血管周围炎性细胞浸润。诊断:炎性线状疣状表皮痣。患者左足部及左侧腘窝接受手术治疗,术后恢复良好,目前正在随访中。

A Report of Familial Inflammatory Linear Verrucous Epidermal Nevus

A 1-year-old girl was first seen with linear erythematous plaques and popular on the left limbs for one year.The parents noticed erythema on the left limb when the girl born after 10 days,which slowly increased in size and distribution.The lesions were extremely pruritic.Her grandmother and mother had similar lesions.There was no family history of psoriasis.Her general physical and systemic examination results were normal.The lesions consisted of linear,scaly,erythematous plaques and popular on the left foot,popliteal fossae,groin and between the fourth and fifth fingers of the left hand.Furthermore,some nails were also involved.Histopathologic examination of lesion from left foot showed hyperkeratosis,focal parakeratosis,acanthosis,papillary hyperplasia,lymphocytic infiltration in the superficial dermis and surrounding the vessels.The diagnosis of inflammatory linear verrucous epidermal nevus was considered according to lesions features and histological results.The left foot and popliteal fossa lesions underwent surgical excision and the areas healed well with no complications and she is followed up.