乙型肝炎肝硬化患者血清CA-125表达水平临床研究

目的 分析不同阶段肝炎、肝硬化患者血清CA-125的变化特征,探讨血清CA-125检测在肝炎肝硬化方面的临床应用价值.方法 从解放军第三○二医院2008年1月到12月住院的乙肝后肝硬化患者中随机选取200例,通过血清胆红素、腹水、血清白蛋白浓度、凝血酶原时间及一般状况等5个指标进行Child-Pugh肝功能分级,并通过电化学发光法检测血清CA-125水平.结合临床诊断进行分类分组,采用SAS软件进行统计学处理.结果 腹水的产生与血清CA-125表达水平相关性具有统计学意义,血清CA-125水平的突然增高预示着肝功能恶化;肝炎肝硬化合并原发性腹膜炎,可引起血清CA-125水平显著升高;本研究未发现血清CA-125水平与原发性肝癌的发生具有统计学相关性;血清CA-125与常见肝功能指标（如ALT、AST、ALB、TBIL）及凝血功能指标PT间皆无线性相关性.结论 血清CA-125表达水平,对于预示非癌性肝炎肝硬化患者肝功能恶化程度具有一定应用价值,可作为腹水存在与否的实验室常规监测指标,对于原发性肝癌的辅助诊断价值尚需进一步探讨.

Evaluation on clinical value of serum CA-125 level in hepatitis cirrhosis

Objective To determine the association between elevated levels of serum cancer antigen (CA) 125 and hepatitis cirrhosis in different stage, and also to explore the clinical application value of serum CA-125. Methods During June to December in 2008, 200 cases with hepatitis cirrhosis were random selected in our hospital. CA-125 levels were measured by electrochemiluminescence immunization assay in sera collected from these cases which were termed with Child-Paugh classification and analyzed by SAS. Results Serum CA-125 levels were correlated closely with ascites, primary peritonitis and liver function Child-Paugh classification, but no associated with primary carcinoma of liver and other liver function index,such as ALT, AST, ALB, TBIL and PT. Conclusion The levels of serum CA-125 in hepatitis cirrhosis patients were osculating correlating with lesion of liver and ascite degree, could serve as a sensitive and conventional laboratory index for liver lesion degree and monitoring ascite generation. It was necessary to further study on the association with serum CA-125 level with primary hepatic carcinoma.