儿童传染性单核细胞增多症多个临床检测指标的诊断价值

 目的探讨儿童传染性单核细胞增多症(infectiousmononucleosis，IM)的检测指标的诊断价值。方法观察101例IM患儿发热天数与多种检测指标，如EB病毒DNA(DNAcopiesofEpstein-Barrvirus，EBV-DNA)、EB衣壳蛋白(viralcapsidantigen，VCA)抗体、异型淋巴细胞、血液中WBC和ALT等指标之间的关系。结果IM患儿的发热天数与多种检测指标的关系用散点图趋势分析提示，不同的检测指标随着发热天数变化趋势不同。IM患儿在发热早期和中期(发热8d内)，EBV-DNA和IgG-VCA的检出阳性率较高(分别是77.2%和76.9%);发热后期EBV-DNA和IgG-VCA(发热12d后)迅速下降。结论在IM患儿发热的初期和中期检测EBV-DNA和VCA的IgG抗体，有助于患儿的特异性诊断。

Analysis of multiple clinical indicator detections for diagnosis of children infectious mononucleosis

Objective To study diagnosis values of multiple clinical detectors including DNA copies of Epstein-Barr virus (EBV) , antibodies of EB viral capsid antigen (VCA), atypical lymphocytes, white blood cells (WBC) and alanine aminotransferase (ALT) in different fever’s days of children infectious mononucleosis (IM). Methods The relationships were tested between fevers’ days and each value of EBV-DNA, atypical lymphocytes, WBC, ALT and VCA antibody in 101 cases of children IMs by scatter plot analysis. Results The results indicated the trends were different among multiple clinical detectors. Detection rates of EBV-DNA and IgG-VCA in early and mid-fever stage (within 8 fevers’ days) were relatively high (77.2% and 76.9% respectively). The two dectectors went down dramatically after fever 12 days. Conclusions Detection of EBV-DNA in early fever stage and IgG-VCA in mid-fever stage in children have high values for diagnosis of IM.