| 糖尿病性角膜病变发病机制的研究进展 |
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| 引用本文： | 吴蓉,陆晓和.糖尿病性角膜病变发病机制的研究进展[J].国际眼科杂志,2020,20(1):61-64. |
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| 作者姓名： | 吴蓉 陆晓和 |
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| 作者单位： | 510280 中国广东省广州市,南方医科大学珠江医院眼科;510280 中国广东省广州市,南方医科大学珠江医院眼科 |
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| 摘 要： | 糖尿病性角膜病变(diabetic keratopathy,DK)是糖尿病在眼部的常见并发症之一,其主要临床表现包括干眼症、点状角膜炎、角膜上皮再生迟缓、反复的上皮糜烂、角膜知觉减退和角膜水肿等,主要发病机制为糖基化反应、多元醇通路和蛋白酶改变等。本文就糖尿病角膜病变的主要临床表现相对应的发病机制进行综述,以期对临床治疗提供新思路。
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| 关 键 词： | 糖尿病 角膜病变 临床表现 发病机制 醛糖还原酶途径 |
| 收稿时间： | 2019/6/13 0:00:00 |
| 修稿时间： | 2019/11/26 0:00:00 |
Research progress in pathogenesis of diabetic keratopathy |
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| Rong Wu and Xiao-He Lu.Research progress in pathogenesis of diabetic keratopathy[J].International Journal of Ophthalmology,2020,20(1):61-64. |
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| Authors: | Rong Wu and Xiao-He Lu |
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| Affiliation: | Department of Ophthalmology, Southern Medical University Zhujiang Hospital, Guangzhou 510280, Guangdong Province, China and Department of Ophthalmology, Southern Medical University Zhujiang Hospital, Guangzhou 510280, Guangdong Province, China |
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| Abstract: | Diabetic keratopathy is one of the common complications of diabetes in the eye, the main clinical manifestations include dry eye diseases, punctate keratitis, slow regeneration of cornea epithelial, recurrent epiththelial erosions, degeneration of corneal sensitivity and corneal edema. The main pathogenesis is AGES, polyol pathway, the changes of proteinases, etc. This article mainly reviews the pathogenesis of its main clinical manifestations,expect to provide new ideas for clinical treatment. |
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| Keywords: | diabetics keratopathy clinical manifestations pathogenesis aldose reductase pathway |
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