盐酸戊乙奎醚与阿托品治疗急性有机磷中毒的疗效比较

目的：比较观察盐酸戊乙奎醚与阿托品治疗急性有机磷中毒（AOPP）的疗效及安全性。方法：将96例AOPP患者随机分为两组,各48例,观察组以盐酸戊乙奎醚＋氯解磷定治疗,对照组以阿托品＋氯解磷定治疗,比较两组的治疗效果。结果：观察组比对照组用药次数减少、症状消失时间缩短、药物不良反应少、住院时间短、治愈率高、死亡率低（P均〈0.01）。结论：盐酸戊乙奎醚治疗有机磷中毒优于阿托品,值得在基层医院推广应用。

Efficacy comparison of penehyclidine and atropine for treatment of acute organophosphorus poisoning

Objective： To observe and compare the efficacy and safety of penehyclidine and atropine for the treatment of acute organophosphorus poisoning （AOPP）. Methods： 96 patients with AOPP were randomly divided into two groups, with 48 patients for each group respectively. The observation group was given the PHC ＋ pralidoxime chloride therapy while the control group was given the atropine ＋ pralidoxime chloride therapy, and the treatment efficacies were compared. Results： Compared with the control group, the treatment group had reduced medication times, shorter symptom disappearance time, fewer adverse drug reactions, shorter hospital stay, higher cure rate and lower mortality rate （ P0.01）. Conclusion： PHC is superior to atropine for the treatment of organophosphorus poisoning and thereby worthy of promotion and application in primary hospitals.