| ~(99)Tc~m(CO)_3-BPHRGD的制备及正常鼠体内生物分布 |
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| 引用本文： | 卿晶,陈宝军,罗联哲,阳国桂,洪业,韩振义,胡骥.~(99)Tc~m(CO)_3-BPHRGD的制备及正常鼠体内生物分布[J].核化学与放射化学,2014,36(2):86-91. |
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| 作者姓名： | 卿晶 陈宝军 罗联哲 阳国桂 洪业 韩振义 胡骥 |
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| 作者单位： | 1.中国原子能科学研究院 同位素研究所，北京102413；2.原子高科股份有限公司，北京102413；3.门头沟区食品药品监督管理局，北京102300 |
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| 摘 要： | 制备了99 Tc m(CO)3-BPHRGD,并进行体内外生物学评价。在pH=7、75℃条件下反应30min,99 Tc m(CO)3-BPHRGD的标记率均大于80%,纯化后标记物的放射化学纯度大于98%;体外稳定性实验显示,在37℃时,标记物在生理盐水、胎牛血清及半胱氨酸溶液中具有很好的稳定性;正常小鼠体内生物分布数据显示,99 Tc m(CO)3-BPHRGD在血液中清除较快,主要通过肝肾代谢。
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| 关 键 词： | RGD 99Tcm 整合素&alpha v&beta 3 生物分布 |
Preparation of 99Tcm(CO)3-BPHRGD and Biodistribution Evaluation in Normal Mice |
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| QING Jing;CHEN Bao-jun;LUO Lian-zhe;YANG Guo-gui;HONG Ye;HAN Zhen-yi;HU Ji.Preparation of 99Tcm(CO)3-BPHRGD and Biodistribution Evaluation in Normal Mice[J].Journal of Nuclear and Radiochemistry,2014,36(2):86-91. |
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| Authors: | QING Jing;CHEN Bao-jun;LUO Lian-zhe;YANG Guo-gui;HONG Ye;HAN Zhen-yi;HU Ji |
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| Affiliation: | 1.China Institute of Atomic Energy, P. O. Box 275(104), Beijing 102413, China;2.Atom Hi-Tech Co., Ltd., Beijing 102413, China; 3.Mentougou Food and Drug Administration, Beijing 102300, China |
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| Abstract: | 99Tcm(CO)3-BPHRGD was prepared, and the in vitro and in vivo biological evaluations were completed. The labeling yield of 99Tcm(CO)3-BPHRGD is more than 80% under optimal conditions(pH=7, reacting at 75℃ for 30 min), and the radiochemical purity is more than 98% after purified. Stability in vitro experiments show that the radiolabeled compound shows good stability in physiological saline, fetal bovine serum, and cysteine solution under 37℃. The biodistribution of 99Tcm(CO)3-BPHRGD in normal mice shows that the metabolic pathways are mainly though liver and kidney with rapid clearance in blood. |
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| Keywords: | RGD 99 v biodistribution |
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