超声热化疗联合根治性手术治疗晚期口腔鳞癌的有效性和安全性评价

目的:评价超声热化疗联合根治性手术治疗晚期口腔鳞癌的安全性及可行性.方法:对2015-2016年就诊的9例经明确病理诊断的口腔鳞癌患者行术前超声热化疗.TPF具体方案为d1:顺铂+多西他赛75 mg/m2,静脉滴注;d1～d5:5氟尿嘧啶750 mg/m2,静脉滴注.超声热化疗期间,于化疗开始的第1、3、5、7、9天行超声肿瘤热疗,温度控制在40～42℃,热疗时间为40 min.每例患者行2周期超声热化疗,评价肿瘤局部消退情况.结果:完全缓解1例,部分缓解3例,稳定5例.超声热化疗期间无明显严重不良反应.患者面形及功能保存较好,生存质量有所提高.结论:超声热疗联合TPF化疗方案治疗晚期口腔鳞癌具有协同作用,可提高患者的近期疗效,不良反应较轻,患者可耐受,是一种微创、有效、安全性高的治疗方案.

Safety and efficacy of ultrasound hyperthermia combined with chemotherapy and radical operation for advanced oral squamous cell carcinoma

PURPOSE:To explore the safety and efficacy of ultrasound hyperthermia combined with chemotherapy and radical operation for advanced oral squamous cell carcinoma (OSCC).METHODS:Nine patients who had definite pathological diagnosis were enrolled in this clinical trail from 2015 to 2016.All patients underwent ultrasound hyperthermia combined with chemotherapy before radical operation.The treatment regime was as follows:Docetaxel and cisplatin (75mg/m2) used on the first day,fluorouracil (750 mg/m2) infused from 1st to 5th day.All patients received 2 cycles of thermo-chemotherapy,the therapeutic temperature was set to be 40-42 ℃C,ultrasound hyperthermia was performed for 40 minutes every other day for 5 times.The therapeutic outcomes were evaluated by observation of clinical tumor regression.RESULTS:Of the 9 patients,complete response (CR)was seen in 1 case,partial response (PR) was seen in 3 cases,stable disease (SD)was seen in 5 cases.Complications were not severe and tolerable.CONCLUSIONS:Ultrasound hyperthermia combined with chemotherapy (TPF) may improve the therapeutic effect in advanced OSCC without obvious adverse reactions,and the toxicity and side effects are well tolerated.