纯红系白血病(M6b)一例报告——附文献复习

目的 提高对纯红系白血病(M6b)生物学本质的认识.方法 报告1例纯红系白血病患者的临床和实验室检查特征、治疗经过、预后并结合文献复习讨论.结果 患者骨髓原始红细胞占0.904,免疫表型:CD71+细胞占99.5%、血型糖蛋白A(GPA)+细胞占67.4%,无干祖细胞、髓系、淋系、巨核系抗原表达,予以HAG(高三尖杉酯碱+阿糖胞苷+G-CSF)方案化疗无效,病情持续进展,多发性髓外浸润,很快死于多器官功能衰竭.结论 纯红系白血病恶性程度高,对常规化疗方案治疗无效,预后极差.

Clinical features of pure erythroid leukemia——case report and review of literature

Objective To report a case of pure erythroid leukemia.Methods The clinical features,treatment and prognosis of a rare case of pure erythroid leukemia were reported,and the related literature was reviewed.Results The pure erythroid leukemia patient was diagnosed by 90.4% pronormoblasts in bone marrow,99.5% for erythroid antigen CD71,67.4% for glycophorin A were detected,while no differentiation antigen of myeloid,lymphoid and megakaryocyte lineages were observed.HAG(homoharringtonine+Cytarabine and G-CSF)regimen were administered with no effect.The patient developed multiple organ failure and died soon.Conclusion Pure erythroid leukemia has a fulminant clinical course with poor response to chemotherapy and worse prognosis.