Study on protection of acanthopanax senticosus injection to sciatic nerve injury in rats

Objective:To study the protection of acanthopanax senticosus injection to sciatic nerve injury in rats.Methods:SD rats were randomly divided into normal group,model group,treatment group 1(20mg/kg.d),treatment group 2(40mg/kg.d).The left sciatic nerves of rats were performed with chucking method to establish sciatic nerve injury model,injection continued for 6 weeks from then on.Observe the temperature of left foot skin,the rat sciatic nerve function index(SFI),the sciatic nerve conduction velocity(SNCV)and the morphological changes of nerve tissue,immunohistochemical staining and Western Blot were used to observe the expression of nerve growth factor.Results:Acanthopanax senticosus injection(20mg/kg.d,0mg/kg.d)can raise the rat skin temperature,promote the function recovery of sciatic nerve,accelerate the conduction velocity of sciatic nerve,make the morphological changes of nerve tissue better,increased the expression of nerve growth factor,and there was a significant difference between this two treatment groups.Conclusions:Protective effect of acanthopanax senticosus injection on peripheral nerve injury in rats may be associated with promoting the expression of nerve growth factor.