睡眠障碍对机体免疫功能及脓毒症发生发展的影响

背景 神经免疫内分泌系统在脓毒症发生发展的过程中发挥着关键的作用,而睡眠障碍显著影响机体神经免疫系统的功能.不同类型睡眠障碍导致的机体免疫功能紊乱在脓毒症研究中受到越来越多的关注. 目的 系统阐述不同类型睡眠障碍对机体免疫功能的调控及对脓毒症发生发展的影响,为进一步完善脓毒症的神经-免疫-内分泌治疗提供防治新策略. 内容 综述睡眠障碍的类型和其对免疫功能及脓毒症发生发展的基础与临床研究进展. 趋向 睡眠障碍是目前普遍存在且严重影响人类健康的社会问题,由此引起的神经免疫内分泌功能障碍导致脓毒症患者预后不佳,神经-免疫-内分泌调节将开启脓毒症治疗的新靶向.

Sleep disorders have an influence on immune function and the development of sepsis

Background Neuro-immune-endocrine system plays an important role in the pathological process of sepsis,sleep disorders intervenes significantly the function of neuro-immune system.We pay more attention to some studies of sepsis about that different types of sleep disorders can lead to immune dysfunction.Objective This review elucidates that diverse sleep disorders have influence on immune system regulation and the development of sepsis.This review also summarizes new control strategies for the neural-immune-endocrine treatment of sepsis.Content We summarize sleep disorder types,animal and clinical studies about influences of sleep disorders on immune function and the development of sepsis.Trend Sleep disorders are widespread social problems that influence human health seriously.It causes neuro-immune-endocrine dysfunction which leads to poor prognosis of sepsis.Thus,regulation of neuro-immune-endocrine system will open the new targeting of sepsis treatment.