| 肥厚性扁平苔藓皮损中浸润淋巴细胞的研究 |
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| 引用本文： | 狄正鸿,许静,周卓,何萍.肥厚性扁平苔藓皮损中浸润淋巴细胞的研究[J].中国组织化学与细胞化学杂志,2008,17(1):20-23. |
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| 作者姓名： | 狄正鸿 许静 周卓 何萍 |
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| 作者单位： | 1. 中国医科大学附属盛京医院皮肤科,沈阳,110004
2. 中国医科大学附属盛京医院中心实验室,沈阳,110004 |
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| 摘 要： | 目的探讨淋巴细胞浸润在肥厚性扁平苔藓发病机制中的意义。方法采用免疫组织化学SP法对10例肥厚性扁平苔藓患者皮损、20例非肥厚性扁平苔藓患者皮损及10例正常人皮肤中CD3、CD4、CD8、CD20进行检测。结果所有患者皮损均以CD3^＋’T、CD4^＋T、CD8^＋T细胞浸润为主，散在CD20^＋B细胞浸润。肥厚性皮损中浸润T淋巴细胞数少于非肥厚性皮损（P〈0．01），CD20^＋B细胞占浸润淋巴细胞百分率高于非肥厚性皮损（P〈0．05）。正常人皮肤仅在真皮偶见CD3^＋T细胞。结论肥厚性扁平苔藓皮损T淋巴细胞的减少，B淋巴细胞的增多表达可能与疾病的持续存在及局部过度增殖性改变密切相关。
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| 关 键 词： | 扁平苔藓 淋巴细胞 CD 肥厚性 扁平苔藓 皮损 浸润淋巴细胞 研究 LICHEN HYPERTROPHIC LESIONS LYMPHOCYTES 相关 变密 增殖性 局部 持续存在 疾病 多表达 真皮 百分率 细胞数 结果 |
| 修稿时间： | 2007年8月22日 |
STUDY OF INFILTRATING LYMPHOCYTES IN LESIONS OF HYPERTROPHIC LICHEN PLANUS |
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| Di Zhenghong,Xu Jing,Zhou Zhuo,He Ping.STUDY OF INFILTRATING LYMPHOCYTES IN LESIONS OF HYPERTROPHIC LICHEN PLANUS[J].Chinese Journal of Histochemistry and Cytochemistry,2008,17(1):20-23. |
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| Authors: | Di Zhenghong Xu Jing Zhou Zhuo He Ping |
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| Affiliation: | Di Zhenghong*,Xu Jing,Zhou Zhuo1,He Ping (Department of Dermatology,1Central Laboratory,Shengjing Hospital,China Medical University,Shenyang 110004,China) |
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| Abstract: | Objective To investigate the role of infiltrating lymphocytes in the lesions of hypertrophic lichen planus.Methods The expressions of CD3,CD4,CD8 and CD20 were detected by immunohistochemistry in the lesions of 10 patients with hypertrophic lichen planus and 20 with non-hypertrophic lichen planus,and in 10 cases of normal human skin tissues.Results For all the patients,the infiltrating cells were mainly CD3+,CD4+ and CD8+T lymphocytes,while CD20+B cells were diffusedly distributed in lichen planus lesions.F... |
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| Keywords: | Lichen planus Lymphocyte CD |
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