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| 环孢素A微乳口服液的制备及稳定性研究 | |
| 引用本文： | 王晓黎,蒋雪涛,刘皋林,钱方.环孢素A微乳口服液的制备及稳定性研究[J].中国现代应用药学,2004,21(1):40-43. |
| 作者姓名： | 王晓黎 蒋雪涛 刘皋林 钱方 |
| 作者单位： | 1. 第二军医大学海医系军队卫生教研室,上海,200433 2. 第二军医大学药学院药剂教研室,上海,200433 3. 第二军医大学附属长征医院,上海,200433 |
| 摘 要： | 目的以环孢素A为模型药物,研究微乳制剂在药剂学上的应用.方法根据微乳的拟三元相图,筛选微乳的处方,制备环孢素A微乳,以冷冻蚀刻电镜法和动态光散射法分别考察其形态和粒径,采用高效液相方法测定微乳中环孢素A浓度,考察含量及稳定性.结果环孢素A微乳制备简单,粒径分布均匀,是一稳定的制剂.结论微乳在药学上有广阔的应用前景. |
| 关 键 词： | 微乳 环孢素A |
| 文章编号： | 1007-7693(2004)01-0040-04 |
The preparation and stability of cyclosporine A microemulsion oral solution |
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| WANG Xiao-li,JIANG Xue-tao,LIU Gao-lin,QIANG Fang.The preparation and stability of cyclosporine A microemulsion oral solution[J].The Chinese Journal of Modern Applied Pharmacy,2004,21(1):40-43. | |
| Authors: | WANG Xiao-li JIANG Xue-tao LIU Gao-lin QIANG Fang |
| Abstract: | OBJECTIVE To study the application of microemulsions in pharmaceuticals with cyclosporine A as a model drug. METHOD Pseudo-ternary phase diagram was used to select the formula of microemulsion and to prepare the cyclosporine A microemulsion. Drop shape and particle size were investigated by freeze-fracture transmission electron microscopy and dynamic light scattering, the concentration and stability of cyclosporine A in microemulsion were determined by HPLC .RESULTS The preparation of cyclosporine A microemulsion is easy and its stablity has been good during three months.CONCLUSION Microemulsions can offer an intersting and potentially powerful way for drug delivery. |
| Keywords: | microemulsion cyclosporine A |
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