The effect of oral appliance therapy on blood pressure in patients with obstructive sleep apnea |
| |
Authors: | Ryo Otsuka Fernanda Ribeiro de Almeida Alan A Lowe Wolfgang Linden Frank Ryan |
| |
Affiliation: | (1) Division of Orthodontics, Department of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, Canada;(2) Maxillofacial Orthognathics, Maxillofacial/Neck Reconstruction, Graduate School of Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyo-ku, Tokyo 113-8549, Japan;(3) Department of Psychology, The University of British Columbia, Vancouver, Canada;(4) Department of Medicine, Division of Respiratory Medicine, Faculty of Medicine, The University of British Columbia, Vancouver, Canada |
| |
Abstract: | The objective of the study was to investigate the effects of oral appliance (OA) therapy on ambulatory blood pressure in patients
with obstructive sleep apnea (OSA). Eleven OSA patients who received OA therapy were prospectively investigated. Ambulatory
blood pressure was measured for 20 h from 4:00 p.m. to 12:00 noon the next day using an ambulatory blood pressure monitor. The Respiratory Disturbance Index (RDI) was measured
in the pretreatment and posttitration periods. The OA was titrated to reach a therapeutic jaw position over 2 to 8 months,
and posttitration measurements were repeated. At posttitration, the RDI was significantly decreased from a mean (SD) of 24.7
(20.1) to 6.1 (4.5). Significant reductions in diastolic blood pressure (DBP) and mean arterial pressure (MAP) were found
for the 20-h periods, and systolic blood pressure (SBP), DBP, and MAP while asleep. The mean values were 79.5 (5.5) to 74.6
(6.0) for DBP and 95.9 (5.4) to 91.2 (5.9) for MAP, for over a 20-h period, and 118.4 (10.0) to 113.7 (9.1) for SBP, 71.6
(8.0) to 67.2 (7.9) for DBP, and 88.4 (8.0) to 83.9 (7.5) for MAP, while asleep. This study suggests that successful OSA treatment
with an OA may also be beneficial to lower blood pressure in OSA patients, as previously suggested for nasal continuous positive
airway pressure therapy.
This study was conducted in the Division of Orthodontics, The University of British Columbia, Canada |
| |
Keywords: | Blood pressure monitoring Ambulatory Sleep apnea Obstructive Mandibular advancement |
本文献已被 SpringerLink 等数据库收录! |
|