老年人孤立性、继发性房颤与KCNQ1多态性探讨 |
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引用本文: | 梁旭,杨纯玉,徐笑洋,李凤翘,翟丽华.老年人孤立性、继发性房颤与KCNQ1多态性探讨[J].中国误诊学杂志,2009,9(14):3285-3286. |
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作者姓名: | 梁旭 杨纯玉 徐笑洋 李凤翘 翟丽华 |
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作者单位: | 广东省深圳市人民医院老年病科,暨南大学医学院第二附属医院,518000 |
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摘 要: | 目的:研究KCNQ1基因多态性与老年人孤立性、继发性心房颤动的关系。方法:选出老年人孤立性心房颤动患者15例,继发性房颤35例,无心房颤动同期住院患者65例为病房对照组,年轻健康体检对照组100例,应用基因芯片技术检测病例组与对照组KCNQ1基因多态性。结果:在深圳汉族人未发现KCNQ1 G等位基因,各研究组GS GG基因型频率为0。结论:本研究未发现KCNQ1 G等位基因,KCNQ1基因多态性与老年人孤立性、继发性心房颤动无相关性。
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关 键 词: | 心房颤动/遗传学 多态现象 遗传 人类 老年人 |
Relationship beteen Lone Atrial Fibrillation or Secondary Atrial Fibrillation in Aged People and KCNQ 1 Gene Polymorphisms |
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Affiliation: | LIANG Xu ,YANG Chun-yu ,XU Xiao yang,et al.(Department of Gerontology; The Second Affiliated Hospital of Jinan Medical College ;Jinan 518000 ,China) |
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Abstract: | Objective:To investigate the association of KCNQ1 gene polymorphisms with lone atrial fibrillation or secondary atrial fibrillation in aged people. Methods:The study included 15 lone atrial fibrillation patients and 35 sec ondary atrial fibrillation in aged people and 65 controls, 100 heathy controls. Gene chip was performed. Results :KCNQ1 G alleles was scare. No statistically significant diffence was,observed in KCNQ1 genotype distribution. Conclusion: We have not found relationship between KCNQ1 gene polymorphisms and lone atrial fibrillation or secondary atrial fibrillation in aged people. |
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Keywords: | Atrial Fibrillation/genetics Polymorphism Genetic Humans Aged |
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