2型糖尿病患者皮下?大网膜脂肪组织脂联素mRNA表达变化及意义

目的:观察2型糖尿病患者皮下及大网膜脂肪组织脂联素(adiponectin)表达水平的变化,及其与血清脂联素、体质指数(BMI)、腰围(WC),腰/臀比值(WHR)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、尿酸(UA)等相关指标的关系,探讨脂联素在2型糖尿病患者发生胰岛素抵抗中的作用。方法:用半定量RT-PCR方法检测23例2型糖尿病合并肥胖患者(DM+FAT)、23例2型糖尿病患者(DM)、33例非糖尿病肥胖患者(control+FAT)、23例非糖尿病患者(control)腹部皮下及大网膜脂肪组织脂联素mRNA的表达水平,并测量身高、体重、腰围、臀围、血压、FPG、HbA1C、血脂、尿酸、血清脂联素,并计算BMI、WHR。结果:①糖尿病肥胖组SBP、DBP、FPG、HbA1c、TG、LDL-C、尿酸均高于对照肥胖组,HDL-C、皮下及大网膜脂肪组织脂联素mRNA表达量、血清脂联素均低于对照肥胖组(P<0.01)。两组的大网膜脂联素表达量低于其皮下表达量(P<0...

Expression and significance of adiponectin mRNA in subcutaneous and omental adipose tissue of type 2 diabetic patients

Objective:To observe the adiponectin mRNA expression in subcutaneous and omental adipose tissue of type 2 diabetic patients and their relation with serum adiponectin,body mass index(BMI),waist circumference(WC),waist hip ratio(WHR),blood pressure,fasting plasma glucose(FPG),HbA1c,blood lipids and uric acid(UA).Methods:Twenty-three T2DM patients with obesity,23 T2DM patients,33 obesity patients and 23 controls were selected.The adiponectin mRNA expression level in adipose tissue was assayed by RT-PCR.The lev...