5508株临床分离病原菌的分布及耐药分析

目的 了解医院住院患者标本中病原菌的分布及其耐药状况.方法 对2007-2008年住院病例临床标本分离菌株及其耐药性进行回顾性调查,并进行统计分析.结果 2007-2008年共分离出病原菌5508株,其中G-杆菌2441株,占44.32%,G~+球菌1154株,占20.95%,真菌1906株,占34.60%;肠杆菌科产ESBLs菌株331株,占19.30%;大肠埃希菌对头孢他啶、庆大霉素、环丙沙星、哌拉西林耐药率均>60.00%,阴沟肠杆菌对庆大霉素、哌拉西林、头孢他啶耐药率均>50.00%,肺炎克雷伯菌对环丙沙星、阿米卡星、庆大霉素、头孢他啶耐药率均<30.00%,未发现大肠埃希菌、阴沟肠杆菌、肺炎克雷伯菌对亚胺培南耐药的菌株;铜绿假单胞菌对亚胺培南、阿米卡星、环丙沙星耐药率均<20.00%,鲍氏不动杆菌对其耐药率均>40.00%;耐甲氧西林葡萄球菌199株,未发现耐万古霉素葡萄球菌菌株.结论 分离菌株的耐药现象普遍存在,临床应重视病原学检查,开展细菌耐药性监测,合理使用抗菌药物.

Distribution and Drug Resistance Analysis of 5508 Pathogens

OBJECTIVE To study the distribution and drug resistance conditions of inpatients in our hospital and make us antibiotics use reasonable. METHODS Retrospective analysis was conducted from all the pathogens of the clinical specimens from 2007-2008 and the data were analysed. RESULTS A total of 5508 pathogens were isolated from 2007-2008. Among 2441 pathogens (44.32 %), there were Gram-negative bacilli(Enterobacteriaceae 1715 pathogens, Nonfermenters 707 pathogens, Vibrionaceae 19 pathogens), 1154 pathogens (20.95%) were Gram-positive bacilli, 1906 pathogens (34.60%) were Fungi. There were 331 pathogens which extended spectrum β-lactamases (ESBLs) of Enterobacteriaceae (19.30%). The resistance of Escherichia coli to amikacin,ceftazidime, gentamicin, ciprofloxacin, piperacillin resistance rates were 10.94%, 60.53%, 62.08%, 82.01%,86.46%, resistance of Enterobacter cloacae to amikacin, ciprofloxacin, gentamicin, piperacillin, ceftazidime resistance rates were 30.61%, 46.29%, 52.96%, 55.20%, 53.05%, resistance of Klebsiella pneumoniae to ciprofloxacin, amikacin, gentamicin, ceftazidime, piperacillin resistance rates were 13.04%, 15.90%, 16.90%,20.17%, 30.07%, The resistance of E. coli, E. coli to ceftazidime, gentamicin, ciprofloxacin, piperacillin were not found were than 60.00%, E. cloacae to gentamicin, piperacillin, ceftazidime not more than 50.00%, K.pneumoniae to ciprofloxacin, amikacin, gentamicin, ceftazidime resistance rates more than 30.00%, not found E.coli, E. cloacae, K. pneumoniae PEI-pei South-resistant strains. The resistance of Pseudomonas aeruginosa to imipenem, amikacin, ciprofloxacin were less than 20.00%, the resistance rate of Acinetobacter baumannii more than 40.00% of 199 methicillin resistant staphylococcus were not found out vancomycin-resistant S. aureus strains. CONCLUSIONS More of the pathogens show multiple drug resistance. It is urgent for surveillance of bacterial resistance and rational use of anti-microbial agents during the clinical therapy.